Recombinant multi-species MSH3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MSH3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
The Alternative Names of target: D13Em1,DNA mismatch repair protein Msh3,DUP,Divergent upstream protein (DUP),FAP4,MRP1,MSH3,Mismatch repair protein 1 (MRP1),Msh3,REP-1,Rep-3,Rep3,hMSH3

Target products collectionGo to MSH3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1464-Ag-1/ GM-Tg-hg-SE1464-Ag-2 Human MSH3 protein Human
GM-Tg-rg-SE1464-Ag-1/ GM-Tg-rg-SE1464-Ag-2 Rat MSH3 protein Rat
GM-Tg-mg-SE1464-Ag-1/ GM-Tg-mg-SE1464-Ag-2 Mouse MSH3 protein Mouse
GM-Tg-cynog-SE1464-Ag-1/ GM-Tg-cynog-SE1464-Ag-2 Cynomolgus/Rhesus macaque MSH3 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1464-Ag-1/ GM-Tg-felg-SE1464-Ag-2 Feline MSH3 protein Feline
GM-Tg-cang-SE1464-Ag-1/ GM-Tg-cang-SE1464-Ag-2 Canine MSH3 protein Canine
GM-Tg-bovg-SE1464-Ag-1/ GM-Tg-bovg-SE1464-Ag-2 Bovine MSH3 protein Bovine
GM-Tg-equg-SE1464-Ag-1/ GM-Tg-equg-SE1464-Ag-2 Equine MSH3 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1464-Ag-1/ GM-Tg-hg-SE1464-Ag-2; GM-Tg-rg-SE1464-Ag-1/ GM-Tg-rg-SE1464-Ag-2;
GM-Tg-mg-SE1464-Ag-1/ GM-Tg-mg-SE1464-Ag-2; GM-Tg-cynog-SE1464-Ag-1/ GM-Tg-cynog-SE1464-Ag-2;
GM-Tg-felg-SE1464-Ag-1/ GM-Tg-felg-SE1464-Ag-2; GM-Tg-cang-SE1464-Ag-1/ GM-Tg-cang-SE1464-Ag-2;
GM-Tg-bovg-SE1464-Ag-1/ GM-Tg-bovg-SE1464-Ag-2; GM-Tg-equg-SE1464-Ag-1/ GM-Tg-equg-SE1464-Ag-2
Products Name MSH3 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MSH3
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MSH3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.