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Target
sublocation: Secreted Protein/Potential Cytokines.
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. [provided by RefSeq, Oct 2014]
| Target ID |
GM-SE0849
|
| Target Name |
DEFA1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1667
|
| Gene ID |
1667 (Homo sapiens)
|
| Target Alternative Names |
DEF1,DEFA1,DEFA2,Defensin,HNP-1,HNP-1 (HP-1,HP-1,HP1,HP1),MRS,Neutrophil defensin 1,alpha 1
|
| Uniprot Accession |
P59665
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Diagnostics Biomarker
|
| Disease from KEGG |
NOD-like receptor signaling pathway, Staphylococcus aureus infection
|
| Gene Ensembl |
ENSG00000206047
|
Pre-made viral vector of DEFA1 cDNA Clones/ORF Plasmid
DEFA1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1667 | Pre-made Human DEFA1/HP1/MRS siRNA oligo Duplex | 1667 | Human | In-vitro grade; in-vivo grade | Detail |
DEFA1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0849-Ab | Human | Anti-Human DEFA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Diagnostic target antibody | Detail |
DEFA1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0849-Ag | Human | Human DEFA1 recombinant protein | Mammalian cell | Detail |
