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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
| Target ID |
GM-SE0474
|
| Target Name |
SLIT2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
9353
|
| Gene ID |
100068338 (Equus caballus), 101084791 (Felis catus), 20563 (Mus musculus), 360272 (Rattus norvegicus) 534164 (Bos taurus), 595148 (Canis lupus familiaris), 715470 (Macaca mulatta), 9353 (Homo sapiens)
|
| Target Alternative Names |
Drad-1,E030015M03Rik,E130320P19Rik,SLIL3,SLIT2,Slil3,Slit homolog 2 protein,Slit-2,Slit2,b2b1200.1Clo,mKIAA4141,slit-2
|
| Uniprot Accession |
Q9R1B9,Q9WVC1,O94813
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease |
cancer
|
| Disease from KEGG |
Axon guidance
|
| Gene Ensembl |
ENSECAG00000022407, ENSMUSG00000031558, ENSBTAG00000005108, ENSCAFG00845010097, ENSMMUG00000002614, ENSG00000145147
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of SLIT2 cDNA Clones/ORF Plasmid
SLIT2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9353 | Pre-made Human SLIT2/SLIL3/Slit-2 siRNA oligo Duplex | 9353 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo360272 | Pre-made Rat Slit2 siRNA oligo Duplex | 360272 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20563 | Pre-made Mouse Slit2/Slil3/Drad-1 siRNA oligo Duplex | 20563 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715470 | Pre-made Cynomolgus/Rhesus macaque SLIT2 siRNA oligo Duplex | 715470 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084791 | Pre-made Cat/Feline SLIT2 siRNA oligo Duplex | 101084791 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo595148 | Pre-made Dog/Canine SLIT2 siRNA oligo Duplex | 595148 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534164 | Pre-made Bovines/Cattle SLIT2 siRNA oligo Duplex | 534164 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100068338 | Pre-made Equine/Horse SLIT2 siRNA oligo Duplex | 100068338 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SLIT2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0474-Ab | Human | Anti-Human SLIT2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE0474-Ab | Rat | Anti-Rat SLIT2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-SE0474-Ab | Mouse | Anti-Mouse SLIT2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE0474-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SLIT2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE0474-Ab | Cat/Feline | Anti-Cat/Feline SLIT2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE0474-Ab | Dog/Canine | Anti-Dog/Canine SLIT2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE0474-Ab | Bovines/Cattle | Anti-Bovines/Cattle SLIT2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE0474-Ab | Equine/Horse | Anti-Equine/Horse SLIT2 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
SLIT2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0474-Ag | Human | Human SLIT2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE0474-Ag | Rat | Rat SLIT2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE0474-Ag | Mouse | Mouse SLIT2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE0474-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SLIT2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE0474-Ag | Cat/Feline | Cat/Feline SLIT2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE0474-Ag | Dog/Canine | Dog/Canine SLIT2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE0474-Ag | Bovines/Cattle | Bovines/Cattle SLIT2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE0474-Ag | Equine/Horse | Equine/Horse SLIT2 recombinant protein | Mammalian cell | Detail |