Explore RAB8A gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP2278
|
| Target Name |
RAB8A
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4218
|
| Gene ID |
100125881 (Bos taurus), 100147248 (Equus caballus), 100423251 (Macaca mulatta), 101092668 (Felis catus) 117103 (Rattus norvegicus), 17274 (Mus musculus), 403773 (Canis lupus familiaris), 4218 (Homo sapiens)
|
| Target Alternative Names |
MEL,Mel,Oncogene c-mel,RAB8,RAB8A,Rab8,Rab8a,Ras-related protein Rab-8A
|
| Uniprot Accession |
A4FV54,P35280,P55258,P61007,P61006
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
cancer
|
| Disease from KEGG |
Tight junction, Pancreatic secretion
|
| Gene Ensembl |
ENSBTAG00000038696, ENSECAG00000053880, ENSMMUG00000056960, ENSMUSG00000003037, ENSCAFG00845030471, ENSG00000167461
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of RAB8A cDNA Clones/ORF Plasmid
RAB8A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4218 | Pre-made Human RAB8A/MEL/RAB8 siRNA oligo Duplex | 4218 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo117103 | Pre-made Rat Rab8a/Mel/Rab8 siRNA oligo Duplex | 117103 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17274 | Pre-made Mouse Rab8a/Mel siRNA oligo Duplex | 17274 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100423251 | Pre-made Cynomolgus/Rhesus macaque RAB8A siRNA oligo Duplex | 100423251 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092668 | Pre-made Cat/Feline RAB8A siRNA oligo Duplex | 101092668 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403773 | Pre-made Dog/Canine RAB8A/RAB8 siRNA oligo Duplex | 403773 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100125881 | Pre-made Bovines/Cattle RAB8A siRNA oligo Duplex | 100125881 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100147248 | Pre-made Equine/Horse RAB8A siRNA oligo Duplex | 100147248 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
RAB8A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP2278-Ab | Human | Anti-Human RAB8A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP2278-Ab | Rat | Anti-Rat RAB8A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP2278-Ab | Mouse | Anti-Mouse RAB8A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP2278-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque RAB8A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP2278-Ab | Cat/Feline | Anti-Cat/Feline RAB8A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP2278-Ab | Dog/Canine | Anti-Dog/Canine RAB8A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP2278-Ab | Bovines/Cattle | Anti-Bovines/Cattle RAB8A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP2278-Ab | Equine/Horse | Anti-Equine/Horse RAB8A monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
RAB8A VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP2278-Ag | Human | Human RAB8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP2278-Ag | Rat | Rat RAB8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP2278-Ag | Mouse | Mouse RAB8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP2278-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque RAB8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP2278-Ag | Cat/Feline | Cat/Feline RAB8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP2278-Ag | Dog/Canine | Dog/Canine RAB8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP2278-Ag | Bovines/Cattle | Bovines/Cattle RAB8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP2278-Ag | Equine/Horse | Equine/Horse RAB8A VLP (virus-like particle) | HEK293 | Products Developing |