TYROBP/DAP12 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

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Target sublocation: Transmembrane Protein.
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Pre-made viral vector of TYROBP/DAP12 cDNA Clones/ORF Plasmid

TYROBP/DAP12 siRNA/miRNA/oligo for RNA interfence (RNAi)

TYROBP/DAP12 antibody/GMab

TYROBP/DAP12 VLP (virus-like particle)/protein