Explore LIGHT/CD258/TNFSF14 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP1857
|
| Target Name |
LIGHT/CD258/TNFSF14
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8740
|
| Gene ID |
100060470 (Equus caballus), 101096542 (Felis catus), 301133 (Rattus norvegicus), 505521 (Bos taurus) 50930 (Mus musculus), 611306 (Canis lupus familiaris), 701451 (Macaca mulatta), 8740 (Homo sapiens)
|
| Target Alternative Names |
CD258,HVEM-L,HVEML,Herpes virus entry mediator ligand (HVEM-L,Herpesvirus entry mediator ligand),LIGHT,LTg,Ly113,TNFSF14,TNLG1D,Tnfsf14,Tnlg1d,Tumor necrosis factor ligand superfamily member 14
|
| Uniprot Accession |
Q9QYH9,O43557
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway
|
| Gene Ensembl |
ENSECAG00000017522, ENSBTAG00000012223, ENSMUSG00000005824, ENSCAFG00845010429, ENSMMUG00000051945, ENSG00000125735
|
Pre-made viral vector of LIGHT/CD258/TNFSF14 cDNA Clones/ORF Plasmid
LIGHT/CD258/TNFSF14 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8740 | Pre-made Human TNFSF14/LTg/CD258 siRNA oligo Duplex | 8740 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo301133 | Pre-made Rat Tnfsf14/Tnlg1d siRNA oligo Duplex | 301133 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo50930 | Pre-made Mouse Tnfsf14/LTg/HVEML siRNA oligo Duplex | 50930 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo701451 | Pre-made Cynomolgus/Rhesus macaque TNFSF14 siRNA oligo Duplex | 701451 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096542 | Pre-made Cat/Feline TNFSF14/TNLG1D siRNA oligo Duplex | 101096542 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo611306 | Pre-made Dog/Canine TNFSF14/LIGHT/TNLG1D siRNA oligo Duplex | 611306 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505521 | Pre-made Bovines/Cattle TNFSF14/TNLG1D siRNA oligo Duplex | 505521 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060470 | Pre-made Equine/Horse TNFSF14/TNLG1D siRNA oligo Duplex | 100060470 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LIGHT/CD258/TNFSF14 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP1857-Ab | Human | Anti-Human LIGHT/CD258/TNFSF14 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-MP1857-Ab | Rat | Anti-Rat LIGHT/CD258/TNFSF14 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-MP1857-Ab | Mouse | Anti-Mouse LIGHT/CD258/TNFSF14 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-MP1857-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LIGHT/CD258/TNFSF14 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-MP1857-Ab | Cat/Feline | Anti-Cat/Feline LIGHT/CD258/TNFSF14 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-MP1857-Ab | Dog/Canine | Anti-Dog/Canine LIGHT/CD258/TNFSF14 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-MP1857-Ab | Bovines/Cattle | Anti-Bovines/Cattle LIGHT/CD258/TNFSF14 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-MP1857-Ab | Equine/Horse | Anti-Equine/Horse LIGHT/CD258/TNFSF14 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
LIGHT/CD258/TNFSF14 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP1857-Ag | Human | Human LIGHT/CD258/TNFSF14 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP1857-Ag | Rat | Rat LIGHT/CD258/TNFSF14 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP1857-Ag | Mouse | Mouse LIGHT/CD258/TNFSF14 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP1857-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LIGHT/CD258/TNFSF14 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP1857-Ag | Cat/Feline | Cat/Feline LIGHT/CD258/TNFSF14 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP1857-Ag | Dog/Canine | Dog/Canine LIGHT/CD258/TNFSF14 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP1857-Ag | Bovines/Cattle | Bovines/Cattle LIGHT/CD258/TNFSF14 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP1857-Ag | Equine/Horse | Equine/Horse LIGHT/CD258/TNFSF14 VLP (virus-like particle) | HEK293 | Products Developing |