Explore LAT gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
| Target ID |
GM-MP0722
|
| Target Name |
LAT
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
27040
|
| Gene ID |
100064430 (Equus caballus), 101093319 (Felis catus), 16797 (Mus musculus), 27040 (Homo sapiens)
514735 (Bos taurus), 607947 (Canis lupus familiaris), 704656 (Macaca mulatta), 81511 (Rattus norvegicus)
|
| Target Alternative Names |
36 kDa phosphotyrosine adapter protein (pp36),IMD52,LAT,LAT1,Lat,Linker for activation of T-cells family member 1,p36-38,pp36
|
| Uniprot Accession |
O54957,O43561,O70601
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
Ras signaling pathway, Rap1 signaling pathway, NF-kappa B signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Yersinia infection, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
| Gene Ensembl |
ENSECAG00000021184, ENSMUSG00000030742, ENSG00000213658, ENSBTAG00000021249, ENSCAFG00845003673, ENSMMUG00000043332
|
Pre-made viral vector of LAT cDNA Clones/ORF Plasmid
LAT siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo27040 | Pre-made Human LAT/LAT1/pp36 siRNA oligo Duplex | 27040 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81511 | Pre-made Rat Lat siRNA oligo Duplex | 81511 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16797 | Pre-made Mouse Lat/pp36/p36-38 siRNA oligo Duplex | 16797 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704656 | Pre-made Cynomolgus/Rhesus macaque LAT siRNA oligo Duplex | 704656 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093319 | Pre-made Cat/Feline LAT siRNA oligo Duplex | 101093319 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo607947 | Pre-made Dog/Canine LAT siRNA oligo Duplex | 607947 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo514735 | Pre-made Bovines/Cattle LAT siRNA oligo Duplex | 514735 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064430 | Pre-made Equine/Horse LAT siRNA oligo Duplex | 100064430 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LAT antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0722-Ab | Human | Anti-Human LAT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0722-Ab | Rat | Anti-Rat LAT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0722-Ab | Mouse | Anti-Mouse LAT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0722-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LAT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-MP0722-Ab | Cat/Feline | Anti-Cat/Feline LAT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0722-Ab | Dog/Canine | Anti-Dog/Canine LAT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-MP0722-Ab | Bovines/Cattle | Anti-Bovines/Cattle LAT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP0722-Ab | Equine/Horse | Anti-Equine/Horse LAT monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
LAT VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0722-Ag | Human | Human LAT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0722-Ag | Rat | Rat LAT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0722-Ag | Mouse | Mouse LAT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0722-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LAT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-MP0722-Ag | Cat/Feline | Cat/Feline LAT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0722-Ag | Dog/Canine | Dog/Canine LAT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-MP0722-Ag | Bovines/Cattle | Bovines/Cattle LAT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0722-Ag | Equine/Horse | Equine/Horse LAT VLP (virus-like particle) | HEK293 | Products Developing |
