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Target
sublocation: Transmembrane Protein.
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
| Target ID |
GM-MP0586
|
| Target Name |
HLA-DQB1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3119
|
| Gene ID |
3119 (Homo sapiens), 474862 (Canis lupus familiaris)
|
| Target Alternative Names |
CELIAC1,DLA-DQB,DLA-DQB1,DLA-DQBC1,DQ beta 1 chain,DQB,HLA class II histocompatibility antigen,HLA-DQB,HLA-DQB1,IDDM1,MHC class II antigen DQB1
|
| Uniprot Accession |
P01920
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Cell adhesion molecules, Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Intestinal immune network for IgA production, Type I diabetes mellitus, Leishmaniasis, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Influenza A, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSG00000179344
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of HLA-DQB1 cDNA Clones/ORF Plasmid
HLA-DQB1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3119 | Pre-made Human HLA-DQB1/IDDM1/CELIAC1 siRNA oligo Duplex | 3119 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474862 | Pre-made Dog/Canine DLA-DQB1/DQB/DLA-DQB siRNA oligo Duplex | 474862 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
HLA-DQB1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0586-Ab | Human | Anti-Human HLA-DQB1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-MP0586-Ab | Dog/Canine | Anti-Dog/Canine HLA-DQB1 monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
HLA-DQB1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0586-Ag | Human | Human HLA-DQB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-MP0586-Ag | Dog/Canine | Dog/Canine HLA-DQB1 VLP (virus-like particle) | HEK293 | Products Developing |
