Explore CD42c/GP1BB gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene. [provided by RefSeq, Dec 2010]
| Target ID |
GM-MP0486
|
| Target Name |
CD42c/GP1BB
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2812
|
| Gene ID |
111774801 (Equus caballus), 116727 (Rattus norvegicus), 14724 (Mus musculus), 2812 (Homo sapiens)
712129 (Macaca mulatta)
|
| Target Alternative Names |
Antigen CD42b-beta,BDPLT1,BS,CD42C,CD42c,GP-Ib beta,GP1BB,GPIBB,GPIb-beta,GPIbB,GPIbbeta,Gp1bb,Platelet glycoprotein Ib beta chain
|
| Uniprot Accession |
Q9JJM7,P56400,P13224
|
| Protein Sub-location |
Transmembrane Protein
|
| Disease from KEGG |
ECM-receptor interaction, Platelet activation, Hematopoietic cell lineage
|
| Gene Ensembl |
ENSMUSG00000050761, ENSG00000203618
|
Pre-made viral vector of CD42c/GP1BB cDNA Clones/ORF Plasmid
CD42c/GP1BB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2812 | Pre-made Human GP1BB/BS/CD42C siRNA oligo Duplex | 2812 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo116727 | Pre-made Rat Gp1bb siRNA oligo Duplex | 116727 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14724 | Pre-made Mouse Gp1bb siRNA oligo Duplex | 14724 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo712129 | Pre-made Cynomolgus/Rhesus macaque GP1BB siRNA oligo Duplex | 712129 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo111774801 | Pre-made Equine/Horse GP1BB siRNA oligo Duplex | 111774801 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD42c/GP1BB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-MP0486-Ab | Human | Anti-Human CD42c/GP1BB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-MP0486-Ab | Rat | Anti-Rat CD42c/GP1BB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-MP0486-Ab | Mouse | Anti-Mouse CD42c/GP1BB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-MP0486-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD42c/GP1BB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-MP0486-Ab | Equine/Horse | Anti-Equine/Horse CD42c/GP1BB monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
CD42c/GP1BB VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-MP0486-Ag | Human | Human CD42c/GP1BB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-MP0486-Ag | Rat | Rat CD42c/GP1BB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-MP0486-Ag | Mouse | Mouse CD42c/GP1BB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-MP0486-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD42c/GP1BB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-MP0486-Ag | Equine/Horse | Equine/Horse CD42c/GP1BB VLP (virus-like particle) | HEK293 | Products Developing |
