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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
| Target ID |
GM-IP7809
|
| Target Name |
MSH6
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2956
|
| Gene ID |
100068065 (Equus caballus), 100360342 (Rattus norvegicus), 101082303 (Felis catus), 17688 (Mus musculus)
2956 (Homo sapiens), 474585 (Canis lupus familiaris), 540526 (Bos taurus), 715701 (Macaca mulatta)
|
| Target Alternative Names |
DNA mismatch repair protein Msh6,G/T mismatch-binding protein (GTBP,GTBP,GTMBP,GTMBP),Gtmbp,HNPCC5,HSAP,LYNCH5,MMRCS3,MSH-6,MSH6,Msh6,MutS protein homolog 6,MutS-alpha 160 kDa subunit (p160),hMSH6,p160
|
| Uniprot Accession |
P54276,P52701
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer, Colorectal Cancer
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000005949, ENSMUSG00000005370, ENSG00000116062, ENSCAFG00845005493, ENSBTAG00000001424, ENSMMUG00000022842
|
| Target Classification |
|
MSH6 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2956 | Pre-made Human MSH6/GTBP/HSAP siRNA oligo Duplex | 2956 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100360342 | Pre-made Rat Msh6 siRNA oligo Duplex | 100360342 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17688 | Pre-made Mouse Msh6/GTBP/Gtmbp siRNA oligo Duplex | 17688 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715701 | Pre-made Cynomolgus/Rhesus macaque MSH6 siRNA oligo Duplex | 715701 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082303 | Pre-made Cat/Feline MSH6 siRNA oligo Duplex | 101082303 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474585 | Pre-made Dog/Canine MSH6 siRNA oligo Duplex | 474585 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540526 | Pre-made Bovines/Cattle MSH6 siRNA oligo Duplex | 540526 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100068065 | Pre-made Equine/Horse MSH6 siRNA oligo Duplex | 100068065 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MSH6 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP7809-Ab | Human | Anti-Human MSH6 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP7809-Ab | Rat | Anti-Rat MSH6 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP7809-Ab | Mouse | Anti-Mouse MSH6 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP7809-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MSH6 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP7809-Ab | Cat/Feline | Anti-Cat/Feline MSH6 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP7809-Ab | Dog/Canine | Anti-Dog/Canine MSH6 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP7809-Ab | Bovines/Cattle | Anti-Bovines/Cattle MSH6 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP7809-Ab | Equine/Horse | Anti-Equine/Horse MSH6 monoclonal antibody | mab | | Detail |
MSH6 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP7809-Ag | Human | Human MSH6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP7809-Ag | Rat | Rat MSH6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP7809-Ag | Mouse | Mouse MSH6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP7809-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MSH6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP7809-Ag | Cat/Feline | Cat/Feline MSH6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP7809-Ag | Dog/Canine | Dog/Canine MSH6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP7809-Ag | Bovines/Cattle | Bovines/Cattle MSH6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP7809-Ag | Equine/Horse | Equine/Horse MSH6 recombinant protein | Mammalian cell | Detail |
