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Target
sublocation: Introcelluar Protein.
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP6317
|
| Target Name |
eIF4G2/DAP5/EIF4G2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1982
|
| Gene ID |
100071378 (Equus caballus), 100855511 (Canis lupus familiaris), 101089295 (Felis catus), 13690 (Mus musculus) 1982 (Homo sapiens), 286870 (Bos taurus), 361628 (Rattus norvegicus), 705510 (Macaca mulatta)
|
| Target Alternative Names |
AAG1,DAP-5,DAP5,Death-associated protein 5 (DAP-5),E130105L11Rik,EIF4G2,Eif4g2,Eukaryotic translation initiation factor 4 gamma 2,NAT1,Nat1,Natm1,P97,eIF-4-gamma 2,eIF-4G 2,eIF4G 2,eIF4G2,p97
|
| Uniprot Accession |
Q62448,P78344,Q95L46
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Gene Ensembl |
ENSMUSG00000005610, ENSG00000110321, ENSBTAG00000020308, ENSMMUG00000011436
|
eIF4G2/DAP5/EIF4G2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1982 | Pre-made Human EIF4G2/P97/AAG1 siRNA oligo Duplex | 1982 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo361628 | Pre-made Rat Eif4g2 siRNA oligo Duplex | 361628 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13690 | Pre-made Mouse Eif4g2/p97/Nat1 siRNA oligo Duplex | 13690 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705510 | Pre-made Cynomolgus/Rhesus macaque EIF4G2 siRNA oligo Duplex | 705510 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089295 | Pre-made Cat/Feline EIF4G2 siRNA oligo Duplex | 101089295 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100855511 | Pre-made Dog/Canine EIF4G2 siRNA oligo Duplex | 100855511 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo286870 | Pre-made Bovines/Cattle EIF4G2 siRNA oligo Duplex | 286870 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071378 | Pre-made Equine/Horse EIF4G2 siRNA oligo Duplex | 100071378 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
eIF4G2/DAP5/EIF4G2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP6317-Ab | Human | Anti-Human eIF4G2/DAP5/EIF4G2 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP6317-Ab | Rat | Anti-Rat eIF4G2/DAP5/EIF4G2 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP6317-Ab | Mouse | Anti-Mouse eIF4G2/DAP5/EIF4G2 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP6317-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque eIF4G2/DAP5/EIF4G2 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP6317-Ab | Cat/Feline | Anti-Cat/Feline eIF4G2/DAP5/EIF4G2 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP6317-Ab | Dog/Canine | Anti-Dog/Canine eIF4G2/DAP5/EIF4G2 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP6317-Ab | Bovines/Cattle | Anti-Bovines/Cattle eIF4G2/DAP5/EIF4G2 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP6317-Ab | Equine/Horse | Anti-Equine/Horse eIF4G2/DAP5/EIF4G2 monoclonal antibody | mab | | Detail |
eIF4G2/DAP5/EIF4G2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP6317-Ag | Human | Human eIF4G2/DAP5/EIF4G2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP6317-Ag | Rat | Rat eIF4G2/DAP5/EIF4G2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP6317-Ag | Mouse | Mouse eIF4G2/DAP5/EIF4G2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP6317-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque eIF4G2/DAP5/EIF4G2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP6317-Ag | Cat/Feline | Cat/Feline eIF4G2/DAP5/EIF4G2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP6317-Ag | Dog/Canine | Dog/Canine eIF4G2/DAP5/EIF4G2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP6317-Ag | Bovines/Cattle | Bovines/Cattle eIF4G2/DAP5/EIF4G2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP6317-Ag | Equine/Horse | Equine/Horse eIF4G2/DAP5/EIF4G2 recombinant protein | Mammalian cell | Detail |