Explore OPTN gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP3298
|
| Target Name |
OPTN
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10133
|
| Gene ID |
100056689 (Equus caballus), 101087414 (Felis catus), 10133 (Homo sapiens), 246294 (Rattus norvegicus)
478003 (Canis lupus familiaris), 534150 (Bos taurus), 574252 (Macaca mulatta), 71648 (Mus musculus)
|
| Target Alternative Names |
4930441O07Rik,ALS12,E3-14.7K-interacting protein (FIP-2),FIP2,Fip2,GLC1E,HIP7,HYPL,Huntingtin yeast partner L,Huntingtin-interacting protein 7 (HIP-7),Huntingtin-interacting protein L,NEMO-related protein,NRP,OPTN,Optic neuropathy-inducing protein,Optineurin,Optn,TFIIIA-INTP,Transcription factor IIIA-interacting protein (TFIIIA-IntP)
|
| Uniprot Accession |
Q96CV9,Q8R5M4,Q861Q8,Q8K3K8
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
Glaucoma
|
| Gene Ensembl |
ENSECAG00000007747, ENSG00000123240, ENSCAFG00845000154, ENSBTAG00000016401, ENSMMUG00000005601, ENSMUSG00000026672
|
Pre-made viral vector of OPTN cDNA Clones/ORF Plasmid
OPTN siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10133 | Pre-made Human OPTN/NRP/FIP2 siRNA oligo Duplex | 10133 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo246294 | Pre-made Rat Optn/Fip2 siRNA oligo Duplex | 246294 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo71648 | Pre-made Mouse Optn/NRP/FIP2 siRNA oligo Duplex | 71648 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574252 | Pre-made Cynomolgus/Rhesus macaque OPTN siRNA oligo Duplex | 574252 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087414 | Pre-made Cat/Feline OPTN siRNA oligo Duplex | 101087414 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478003 | Pre-made Dog/Canine OPTN siRNA oligo Duplex | 478003 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534150 | Pre-made Bovines/Cattle OPTN siRNA oligo Duplex | 534150 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056689 | Pre-made Equine/Horse OPTN siRNA oligo Duplex | 100056689 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
OPTN antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP3298-Ab | Human | Anti-Human OPTN monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP3298-Ab | Rat | Anti-Rat OPTN monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP3298-Ab | Mouse | Anti-Mouse OPTN monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP3298-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque OPTN monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP3298-Ab | Cat/Feline | Anti-Cat/Feline OPTN monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP3298-Ab | Dog/Canine | Anti-Dog/Canine OPTN monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP3298-Ab | Bovines/Cattle | Anti-Bovines/Cattle OPTN monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP3298-Ab | Equine/Horse | Anti-Equine/Horse OPTN monoclonal antibody | mab | | Detail |
OPTN recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP3298-Ag | Human | Human OPTN recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP3298-Ag | Rat | Rat OPTN recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP3298-Ag | Mouse | Mouse OPTN recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP3298-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque OPTN recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP3298-Ag | Cat/Feline | Cat/Feline OPTN recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP3298-Ag | Dog/Canine | Dog/Canine OPTN recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP3298-Ag | Bovines/Cattle | Bovines/Cattle OPTN recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP3298-Ag | Equine/Horse | Equine/Horse OPTN recombinant protein | Mammalian cell | Detail |
