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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
| Target ID |
GM-IP3067
|
| Target Name |
BCL2L11/BIM/Bim
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
10018
|
| Gene ID |
100064312 (Equus caballus), 10018 (Homo sapiens), 101084615 (Felis catus), 12125 (Mus musculus) 507390 (Bos taurus), 612867 (Canis lupus familiaris), 64547 (Rattus norvegicus), 697082 (Macaca mulatta)
|
| Target Alternative Names |
1500006F24Rik,BAM,BCL2L11,BIM,BOD,Bcl-2-like protein 11,Bcl2-L-11,Bcl2-interacting mediator of cell death,Bcl2l11,Bim,BimL,Bod,bcl2-L-11
|
| Uniprot Accession |
O43521,O54918,O88498
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000032970, ENSG00000153094, ENSMUSG00000027381, ENSBTAG00000024105, ENSCAFG00845009241, ENSMMUG00000018423
|
| Target Classification |
Pathway
|
Pre-made viral vector of BCL2L11/BIM/Bim cDNA Clones/ORF Plasmid
BCL2L11/BIM/Bim siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10018 | Pre-made Human BCL2L11/BAM/BIM siRNA oligo Duplex | 10018 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64547 | Pre-made Rat Bcl2l11/Bim/Bod siRNA oligo Duplex | 64547 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12125 | Pre-made Mouse Bcl2l11/Bim/Bod siRNA oligo Duplex | 12125 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697082 | Pre-made Cynomolgus/Rhesus macaque BCL2L11 siRNA oligo Duplex | 697082 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084615 | Pre-made Cat/Feline BCL2L11 siRNA oligo Duplex | 101084615 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo612867 | Pre-made Dog/Canine BCL2L11 siRNA oligo Duplex | 612867 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507390 | Pre-made Bovines/Cattle BCL2L11/Bim siRNA oligo Duplex | 507390 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064312 | Pre-made Equine/Horse BCL2L11 siRNA oligo Duplex | 100064312 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BCL2L11/BIM/Bim antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP3067-Ab | Human | Anti-Human BCL2L11/BIM/Bim monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP3067-Ab | Rat | Anti-Rat BCL2L11/BIM/Bim monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP3067-Ab | Mouse | Anti-Mouse BCL2L11/BIM/Bim monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP3067-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BCL2L11/BIM/Bim monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP3067-Ab | Cat/Feline | Anti-Cat/Feline BCL2L11/BIM/Bim monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP3067-Ab | Dog/Canine | Anti-Dog/Canine BCL2L11/BIM/Bim monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP3067-Ab | Bovines/Cattle | Anti-Bovines/Cattle BCL2L11/BIM/Bim monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP3067-Ab | Equine/Horse | Anti-Equine/Horse BCL2L11/BIM/Bim monoclonal antibody | mab | | Detail |
BCL2L11/BIM/Bim recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP3067-Ag | Human | Human BCL2L11/BIM/Bim recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP3067-Ag | Rat | Rat BCL2L11/BIM/Bim recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP3067-Ag | Mouse | Mouse BCL2L11/BIM/Bim recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP3067-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BCL2L11/BIM/Bim recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP3067-Ag | Cat/Feline | Cat/Feline BCL2L11/BIM/Bim recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP3067-Ag | Dog/Canine | Dog/Canine BCL2L11/BIM/Bim recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP3067-Ag | Bovines/Cattle | Bovines/Cattle BCL2L11/BIM/Bim recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP3067-Ag | Equine/Horse | Equine/Horse BCL2L11/BIM/Bim recombinant protein | Mammalian cell | Detail |