Explore TAP2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]
Target ID |
GM-IP1881
|
Target Name |
TAP2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6891
|
Gene ID |
100052423 (Equus caballus), 101089770 (Felis catus), 21355 (Mus musculus), 24812 (Rattus norvegicus) 281586 (Bos taurus), 474864 (Canis lupus familiaris), 6891 (Homo sapiens), 717742 (Macaca mulatta)
|
Target Alternative Names |
TAP2,Tap2,Y1,jas,APT2,Ham2,MTP2,PSF2,ABC18,Abcb3,Ham-2,Tap-2,RING11,Cim,ABCB3,PSF-2,MHC1D2,D6S217E
|
Uniprot Accession |
P36371,P36372,Q03519
|
Uniprot Entry Name |
|
Protein Sub-location |
Introcelluar Protein
|
Category |
|
Disease |
cancer
|
Disease from KEGG |
ABC transporters, Phagosome, Antigen processing and presentation, Human cytomegalovirus infection, Epstein-Barr virus infection
|
Gene Ensembl |
ENSECAG00000007152, ENSMUSG00000024339, ENSBTAG00000003038, ENSCAFG00845017879, ENSG00000204267, ENSMMUG00000011293
|
Target Classification |
Tumor-associated antigen (TAA)
|
TAP2 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo6891 | Pre-made Human TAP2/APT2/PSF2 siRNA oligo Duplex | 6891 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo24812 | Pre-made Rat Tap2/Cim/Abcb3 siRNA oligo Duplex | 24812 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo21355 | Pre-made Mouse Tap2/Y1/jas siRNA oligo Duplex | 21355 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo717742 | Pre-made Cynomolgus/Rhesus macaque TAP2 siRNA oligo Duplex | 717742 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101089770 | Pre-made Cat/Feline TAP2 siRNA oligo Duplex | 101089770 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo474864 | Pre-made Dog/Canine TAP2/APT2 siRNA oligo Duplex | 474864 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo281586 | Pre-made Bovines/Cattle TAP2/ABCB3 siRNA oligo Duplex | 281586 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100052423 | Pre-made Equine/Horse TAP2 siRNA oligo Duplex | 100052423 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TAP2 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-IP1881-Ab | Human | Anti-Human TAP2 monoclonal antibody | mab | | Detail |
GM-Tg-rg-IP1881-Ab | Rat | Anti-Rat TAP2 monoclonal antibody | mab | | Detail |
GM-Tg-mg-IP1881-Ab | Mouse | Anti-Mouse TAP2 monoclonal antibody | mab | | Detail |
GM-Tg-cynog-IP1881-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TAP2 monoclonal antibody | mab | | Detail |
GM-Tg-felg-IP1881-Ab | Cat/Feline | Anti-Cat/Feline TAP2 monoclonal antibody | mab | | Detail |
GM-Tg-cang-IP1881-Ab | Dog/Canine | Anti-Dog/Canine TAP2 monoclonal antibody | mab | | Detail |
GM-Tg-bovg-IP1881-Ab | Bovines/Cattle | Anti-Bovines/Cattle TAP2 monoclonal antibody | mab | | Detail |
GM-Tg-equg-IP1881-Ab | Equine/Horse | Anti-Equine/Horse TAP2 monoclonal antibody | mab | | Detail |
TAP2 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-IP1881-Ag | Human | Human TAP2 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-IP1881-Ag | Rat | Rat TAP2 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-IP1881-Ag | Mouse | Mouse TAP2 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-IP1881-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TAP2 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-IP1881-Ag | Cat/Feline | Cat/Feline TAP2 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-IP1881-Ag | Dog/Canine | Dog/Canine TAP2 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-IP1881-Ag | Bovines/Cattle | Bovines/Cattle TAP2 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-IP1881-Ag | Equine/Horse | Equine/Horse TAP2 recombinant protein | Mammalian cell | Detail |