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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
| Target ID |
GM-IP1328
|
| Target Name |
PCBP2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5094
|
| Gene ID |
100062163 (Equus caballus), 101086733 (Felis catus), 18521 (Mus musculus), 363005 (Rattus norvegicus) 477596 (Canis lupus familiaris), 5094 (Homo sapiens), 540653 (Bos taurus), 703175 (Macaca mulatta)
|
| Target Alternative Names |
Alpha-CP2,HNRNPE2,HNRPE2,Heterogeneous nuclear ribonucleoprotein E2 (hnRNP E2),Hnrpx,PCBP2,Pcbp2,Poly(rC)-binding protein 2,alphaCP-2,hnRNP-E2
|
| Uniprot Accession |
Q61990,Q15366
|
| Protein Sub-location |
Introcelluar Protein
|
| Disease from KEGG |
Ferroptosis
|
| Gene Ensembl |
ENSECAG00000022389, ENSMUSG00000056851, ENSCAFG00845019393, ENSG00000197111, ENSBTAG00000020757, ENSMMUG00000006608
|
Pre-made viral vector of PCBP2 cDNA Clones/ORF Plasmid
PCBP2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5094 | Pre-made Human PCBP2/HNRPE2/HNRNPE2 siRNA oligo Duplex | 5094 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo363005 | Pre-made Rat Pcbp2 siRNA oligo Duplex | 363005 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18521 | Pre-made Mouse Pcbp2/Hnrpx/alphaCP-2 siRNA oligo Duplex | 18521 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703175 | Pre-made Cynomolgus/Rhesus macaque PCBP2 siRNA oligo Duplex | 703175 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086733 | Pre-made Cat/Feline PCBP2 siRNA oligo Duplex | 101086733 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477596 | Pre-made Dog/Canine PCBP2 siRNA oligo Duplex | 477596 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540653 | Pre-made Bovines/Cattle PCBP2 siRNA oligo Duplex | 540653 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100062163 | Pre-made Equine/Horse PCBP2 siRNA oligo Duplex | 100062163 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PCBP2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP1328-Ab | Human | Anti-Human PCBP2 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP1328-Ab | Rat | Anti-Rat PCBP2 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP1328-Ab | Mouse | Anti-Mouse PCBP2 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP1328-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PCBP2 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP1328-Ab | Cat/Feline | Anti-Cat/Feline PCBP2 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP1328-Ab | Dog/Canine | Anti-Dog/Canine PCBP2 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP1328-Ab | Bovines/Cattle | Anti-Bovines/Cattle PCBP2 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP1328-Ab | Equine/Horse | Anti-Equine/Horse PCBP2 monoclonal antibody | mab | | Detail |
PCBP2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP1328-Ag | Human | Human PCBP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP1328-Ag | Rat | Rat PCBP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP1328-Ag | Mouse | Mouse PCBP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP1328-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PCBP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP1328-Ag | Cat/Feline | Cat/Feline PCBP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP1328-Ag | Dog/Canine | Dog/Canine PCBP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP1328-Ag | Bovines/Cattle | Bovines/Cattle PCBP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP1328-Ag | Equine/Horse | Equine/Horse PCBP2 recombinant protein | Mammalian cell | Detail |