Explore TP63/p63 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
| Target ID |
GM-IP13220
|
| Target Name |
TP63/p63
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8626
|
| Gene ID |
100059752 (Equus caballus), 101095124 (Felis catus), 22061 (Mus musculus), 246334 (Rattus norvegicus) 488125 (Canis lupus familiaris), 615335 (Bos taurus), 703997 (Macaca mulatta), 8626 (Homo sapiens)
|
| Target Alternative Names |
AIS,B(p51A),B(p51B),Chronic ulcerative stomatitis protein (CUSP),EEC3,KET,Keratinocyte transcription factor KET,Ket,LMS,NBP,OFC8,P51/P63,P63,P73l,RHS,SHFM4,TP53CP,TP53L,TP63,TP73L,Tp63,Tp73l,Transformation-related protein 63 (TP63),Trp53rp1,Trp63,Tumor protein 63,Tumor protein p73-like (p73L),p40,p51,p53CP,p63,p73H,p73L
|
| Uniprot Accession |
O88898,Q9JJP6,Q9H3D4
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Life Science Target
|
| Disease |
cancer, Prostate Cancer
|
| Gene Ensembl |
ENSECAG00000018546, ENSMUSG00000022510, ENSCAFG00845023542, ENSBTAG00000015460, ENSMMUG00000016466, ENSG00000073282
|
Pre-made viral vector of TP63/p63 cDNA Clones/ORF Plasmid
TP63/p63 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8626 | Pre-made Human TP63/AIS/KET siRNA oligo Duplex | 8626 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo246334 | Pre-made Rat Tp63/Ket/P73l siRNA oligo Duplex | 246334 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22061 | Pre-made Mouse Trp63/Ket/P63 siRNA oligo Duplex | 22061 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703997 | Pre-made Cynomolgus/Rhesus macaque TP63 siRNA oligo Duplex | 703997 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095124 | Pre-made Cat/Feline TP63 siRNA oligo Duplex | 101095124 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488125 | Pre-made Dog/Canine TP63/TP73L siRNA oligo Duplex | 488125 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo615335 | Pre-made Bovines/Cattle TP63 siRNA oligo Duplex | 615335 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100059752 | Pre-made Equine/Horse TP63 siRNA oligo Duplex | 100059752 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TP63/p63 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP13220-Ab | Human | Anti-Human TP63/p63 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP13220-Ab | Rat | Anti-Rat TP63/p63 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP13220-Ab | Mouse | Anti-Mouse TP63/p63 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP13220-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TP63/p63 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP13220-Ab | Cat/Feline | Anti-Cat/Feline TP63/p63 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP13220-Ab | Dog/Canine | Anti-Dog/Canine TP63/p63 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP13220-Ab | Bovines/Cattle | Anti-Bovines/Cattle TP63/p63 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP13220-Ab | Equine/Horse | Anti-Equine/Horse TP63/p63 monoclonal antibody | mab | | Detail |
TP63/p63 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP13220-Ag | Human | Human TP63/p63 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP13220-Ag | Rat | Rat TP63/p63 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP13220-Ag | Mouse | Mouse TP63/p63 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP13220-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TP63/p63 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP13220-Ag | Cat/Feline | Cat/Feline TP63/p63 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP13220-Ag | Dog/Canine | Dog/Canine TP63/p63 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP13220-Ag | Bovines/Cattle | Bovines/Cattle TP63/p63 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP13220-Ag | Equine/Horse | Equine/Horse TP63/p63 recombinant protein | Mammalian cell | Detail |