Explore CYP1A2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP0643
|
| Target Name |
CYP1A2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1544
|
| Gene ID |
100062244 (Equus caballus), 1544 (Homo sapiens), 503552 (Bos taurus), 554345 (Felis catus)
|
| Target Alternative Names |
CYP1A2,CP12,CYPIA2,P3-450,P450(PA)
|
| Uniprot Accession |
P05177,Q5KQT6
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Steroid hormone biosynthesis, Chemical carcinogenesis - DNA adducts, Chemical carcinogenesis - receptor activation, Linoleic acid metabolism, Retinol metabolism, Drug metabolism - cytochrome P450
|
| Gene Ensembl |
ENSECAG00000008153, ENSG00000140505, ENSBTAG00000000085
|
| Target Classification |
Tumor-associated antigen (TAA)
|
CYP1A2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1544 | Pre-made Human CYP1A2/CP12/CYPIA2 siRNA oligo Duplex | 1544 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo554345 | Pre-made Cat/Feline CYP1A2 siRNA oligo Duplex | 554345 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo503552 | Pre-made Bovines/Cattle CYP1A2 siRNA oligo Duplex | 503552 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100062244 | Pre-made Equine/Horse CYP1A2 siRNA oligo Duplex | 100062244 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CYP1A2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0643-Ab | Human | Anti-Human CYP1A2 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP0643-Ab | Cat/Feline | Anti-Cat/Feline CYP1A2 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP0643-Ab | Bovines/Cattle | Anti-Bovines/Cattle CYP1A2 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP0643-Ab | Equine/Horse | Anti-Equine/Horse CYP1A2 monoclonal antibody | mab | | Detail |
CYP1A2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0643-Ag | Human | Human CYP1A2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0643-Ag | Cat/Feline | Cat/Feline CYP1A2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0643-Ag | Bovines/Cattle | Bovines/Cattle CYP1A2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0643-Ag | Equine/Horse | Equine/Horse CYP1A2 recombinant protein | Mammalian cell | Detail |
