Explore ATF6B gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
| Target ID |
GM-IP0376
|
| Target Name |
ATF6B
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1388
|
| Gene ID |
100059348 (Equus caballus), 101094849 (Felis catus), 12915 (Mus musculus), 1388 (Homo sapiens)
406169 (Rattus norvegicus), 474855 (Canis lupus familiaris), 513928 (Bos taurus), 717050 (Macaca mulatta)
|
| Target Alternative Names |
ATF6B,ATF6beta,Activating transcription factor 6 beta (ATF6-beta),Atf6b,CREB-RP,CREBL1,Creb-rp,Crebl1,Cyclic AMP-dependent transcription factor ATF-6 beta,G13,Protein G13,cAMP response element-binding protein-related protein (Creb-rp),cAMP-dependent transcription factor ATF-6 beta,cAMP-responsive element-binding protein-like 1
|
| Uniprot Accession |
O35451,Q99941
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
|
| Disease |
|
| Disease from KEGG |
cGMP-PKG signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Longevity regulating pathway, Adrenergic signaling in cardiomyocytes, TNF signaling pathway, Insulin secretion, Thyroid hormone synthesis, Aldosterone synthesis and secretion, Relaxin signaling pathway, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Growth hormone synthesis, secretion and action, Cocaine addiction, Amphetamine addiction, Hepatitis B, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Chemical carcinogenesis - receptor activation
|
| Gene Ensembl |
ENSECAG00000021507, ENSMUSG00000015461, ENSG00000213676, ENSCAFG00845014557, ENSBTAG00000008794, ENSMMUG00000015229
|
| Target Classification |
|
ATF6B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1388 | Pre-made Human ATF6B/G13/CREBL1 siRNA oligo Duplex | 1388 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo406169 | Pre-made Rat Atf6b/Crebl1 siRNA oligo Duplex | 406169 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12915 | Pre-made Mouse Atf6b/Crebl1/Creb-rp siRNA oligo Duplex | 12915 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717050 | Pre-made Cynomolgus/Rhesus macaque ATF6B/CREBL1 siRNA oligo Duplex | 717050 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094849 | Pre-made Cat/Feline ATF6B siRNA oligo Duplex | 101094849 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474855 | Pre-made Dog/Canine ATF6B/CREBL1 siRNA oligo Duplex | 474855 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo513928 | Pre-made Bovines/Cattle ATF6B/CREBL1 siRNA oligo Duplex | 513928 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100059348 | Pre-made Equine/Horse ATF6B siRNA oligo Duplex | 100059348 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ATF6B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0376-Ab | Human | Anti-Human ATF6B monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP0376-Ab | Rat | Anti-Rat ATF6B monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP0376-Ab | Mouse | Anti-Mouse ATF6B monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP0376-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ATF6B monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP0376-Ab | Cat/Feline | Anti-Cat/Feline ATF6B monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP0376-Ab | Dog/Canine | Anti-Dog/Canine ATF6B monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP0376-Ab | Bovines/Cattle | Anti-Bovines/Cattle ATF6B monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP0376-Ab | Equine/Horse | Anti-Equine/Horse ATF6B monoclonal antibody | mab | | Detail |
ATF6B recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0376-Ag | Human | Human ATF6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0376-Ag | Rat | Rat ATF6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0376-Ag | Mouse | Mouse ATF6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0376-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ATF6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0376-Ag | Cat/Feline | Cat/Feline ATF6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0376-Ag | Dog/Canine | Dog/Canine ATF6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0376-Ag | Bovines/Cattle | Bovines/Cattle ATF6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0376-Ag | Equine/Horse | Equine/Horse ATF6B recombinant protein | Mammalian cell | Detail |
