Recombinant multi-species ATF6B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATF6B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
The Alternative Names of target: ATF6B,ATF6beta,Activating transcription factor 6 beta (ATF6-beta),Atf6b,CREB-RP,CREBL1,Creb-rp,Crebl1,Cyclic AMP-dependent transcription factor ATF-6 beta,G13,Protein G13,cAMP response element-binding protein-related protein (Creb-rp),cAMP-dependent transcription factor ATF-6 beta,cAMP-responsive element-binding protein-like 1

Target products collectionGo to ATF6B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0376-Ag-1/ GM-Tg-hg-IP0376-Ag-2 Human ATF6B protein Human
GM-Tg-rg-IP0376-Ag-1/ GM-Tg-rg-IP0376-Ag-2 Rat ATF6B protein Rat
GM-Tg-mg-IP0376-Ag-1/ GM-Tg-mg-IP0376-Ag-2 Mouse ATF6B protein Mouse
GM-Tg-cynog-IP0376-Ag-1/ GM-Tg-cynog-IP0376-Ag-2 Cynomolgus/Rhesus macaque ATF6B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0376-Ag-1/ GM-Tg-felg-IP0376-Ag-2 Feline ATF6B protein Feline
GM-Tg-cang-IP0376-Ag-1/ GM-Tg-cang-IP0376-Ag-2 Canine ATF6B protein Canine
GM-Tg-bovg-IP0376-Ag-1/ GM-Tg-bovg-IP0376-Ag-2 Bovine ATF6B protein Bovine
GM-Tg-equg-IP0376-Ag-1/ GM-Tg-equg-IP0376-Ag-2 Equine ATF6B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0376-Ag-1/ GM-Tg-hg-IP0376-Ag-2; GM-Tg-rg-IP0376-Ag-1/ GM-Tg-rg-IP0376-Ag-2;
GM-Tg-mg-IP0376-Ag-1/ GM-Tg-mg-IP0376-Ag-2; GM-Tg-cynog-IP0376-Ag-1/ GM-Tg-cynog-IP0376-Ag-2;
GM-Tg-felg-IP0376-Ag-1/ GM-Tg-felg-IP0376-Ag-2; GM-Tg-cang-IP0376-Ag-1/ GM-Tg-cang-IP0376-Ag-2;
GM-Tg-bovg-IP0376-Ag-1/ GM-Tg-bovg-IP0376-Ag-2; GM-Tg-equg-IP0376-Ag-1/ GM-Tg-equg-IP0376-Ag-2
Products Name ATF6B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ATF6B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATF6B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.