Explore SPTLC1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013]
| Target ID |
GM-IP0242
|
| Target Name |
SPTLC1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10558
|
| Gene ID |
100063025 (Equus caballus), 101087947 (Felis catus), 10558 (Homo sapiens), 268656 (Mus musculus)
361213 (Rattus norvegicus), 484192 (Canis lupus familiaris), 614165 (Bos taurus), 705324 (Macaca mulatta)
|
| Target Alternative Names |
ALS27,E030036H05,HSAN1,HSN1,LBC1,LCB 1,LCB1,Lcb1,Long chain base biosynthesis protein 1 (LCB 1),RGD1306617,SPT 1,SPT1,SPT1),SPTI,SPTLC1,Serine palmitoyltransferase 1,Serine-palmitoyl-CoA transferase 1 (SPT 1,Spt1,Sptlc1
|
| Uniprot Accession |
O15269,O35704,D4A2H2,Q3MHG1
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, Sphingolipid signaling pathway, Sphingolipid metabolism
|
| Gene Ensembl |
ENSECAG00000020998, ENSG00000090054, ENSMUSG00000021468, ENSCAFG00845017253, ENSBTAG00000002220, ENSMMUG00000003006
|
Pre-made viral vector of SPTLC1 cDNA Clones/ORF Plasmid
SPTLC1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10558 | Pre-made Human SPTLC1/HSN1/LBC1 siRNA oligo Duplex | 10558 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo361213 | Pre-made Rat Sptlc1/Lcb1/Spt1 siRNA oligo Duplex | 361213 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo268656 | Pre-made Mouse Sptlc1/Lcb1/SPT1 siRNA oligo Duplex | 268656 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705324 | Pre-made Cynomolgus/Rhesus macaque SPTLC1 siRNA oligo Duplex | 705324 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087947 | Pre-made Cat/Feline SPTLC1 siRNA oligo Duplex | 101087947 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484192 | Pre-made Dog/Canine SPTLC1 siRNA oligo Duplex | 484192 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo614165 | Pre-made Bovines/Cattle SPTLC1 siRNA oligo Duplex | 614165 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063025 | Pre-made Equine/Horse SPTLC1 siRNA oligo Duplex | 100063025 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SPTLC1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0242-Ab | Human | Anti-Human SPTLC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0242-Ab | Rat | Anti-Rat SPTLC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0242-Ab | Mouse | Anti-Mouse SPTLC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0242-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SPTLC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0242-Ab | Cat/Feline | Anti-Cat/Feline SPTLC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0242-Ab | Dog/Canine | Anti-Dog/Canine SPTLC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0242-Ab | Bovines/Cattle | Anti-Bovines/Cattle SPTLC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0242-Ab | Equine/Horse | Anti-Equine/Horse SPTLC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
SPTLC1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0242-Ag | Human | Human SPTLC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0242-Ag | Rat | Rat SPTLC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0242-Ag | Mouse | Mouse SPTLC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0242-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SPTLC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0242-Ag | Cat/Feline | Cat/Feline SPTLC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0242-Ag | Dog/Canine | Dog/Canine SPTLC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0242-Ag | Bovines/Cattle | Bovines/Cattle SPTLC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0242-Ag | Equine/Horse | Equine/Horse SPTLC1 recombinant protein | Mammalian cell | Detail |
