DIABLO/Smac Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore DIABLO/Smac gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Target ID	GM-IP0216
Target Name	DIABLO/Smac
Gene Group ldentifer （Target Gene ID in Homo species)	56616
Gene ID	100058709 (Equus caballus), 288753 (Rattus norvegicus), 477463 (Canis lupus familiaris), 493999 (Bos taurus) 56616 (Homo sapiens), 66593 (Mus musculus), 701896 (Macaca mulatta), 768282 (Felis catus)
Target Alternative Names	0610041G12Rik,1700006L01Rik,DBO,DFNA64,DIABLO,Diablo,Diablo IAP-binding mitochondrial protein,Diablo homolog,Direct IAP-binding protein with low pI,SMAC,Second mitochondria-derived activator of caspases (SMAC),Smac,mitochondrial
Uniprot Accession	Q9NR28,Q9JIQ3
Protein Sub-location	Introcelluar Protein
Disease	cancer
Disease from KEGG	Apoptosis, Apoptosis - multiple species
Gene Ensembl	ENSECAG00000020255, ENSCAFG00845022403, ENSBTAG00000004199, ENSG00000184047, ENSMUSG00000029433, ENSMMUG00000018037
Target Classification	Tumor-associated antigen (TAA)

Pre-made viral vector of DIABLO/Smac cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLV000088	Human DIABLO/DFNA64/SMAC Lentivirus plasmid	NM_019887	56616	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLV000088	Human DIABLO/DFNA64/SMAC Lentivirus particle	NM_019887	56616	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMLPm000817	Mouse Diablo/0610041G12Rik/1700006L01Rik Lentivirus plasmid	NM_023232	66593	Mouse	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLPm000817	Mouse Diablo/0610041G12Rik/1700006L01Rik Lentivirus particle	NM_023232	66593	Mouse	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail

DIABLO/Smac siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo56616	Pre-made Human DIABLO/SMAC/DFNA64 siRNA oligo Duplex	56616	Human	In-vitro grade; in-vivo grade	Detail
pGMoligo288753	Pre-made Rat Diablo/Smac siRNA oligo Duplex	288753	Rat	In-vitro grade; in-vivo grade	Detail
pGMoligo66593	Pre-made Mouse Diablo/Smac/0610041G12Rik siRNA oligo Duplex	66593	Mouse	In-vitro grade; in-vivo grade	Detail
pGMoligo701896	Pre-made Cynomolgus/Rhesus macaque DIABLO siRNA oligo Duplex	701896	Cynomolgus/Rhesus macaque	In-vitro grade; in-vivo grade	Detail
pGMoligo768282	Pre-made Cat/Feline DIABLO siRNA oligo Duplex	768282	Cat/Feline	In-vitro grade; in-vivo grade	Detail
pGMoligo477463	Pre-made Dog/Canine DIABLO/DBO siRNA oligo Duplex	477463	Dog/Canine	In-vitro grade; in-vivo grade	Detail
pGMoligo493999	Pre-made Bovines/Cattle DIABLO/SMAC siRNA oligo Duplex	493999	Bovines/Cattle	In-vitro grade; in-vivo grade	Detail
pGMoligo100058709	Pre-made Equine/Horse DIABLO siRNA oligo Duplex	100058709	Equine/Horse	In-vitro grade; in-vivo grade	Detail

DIABLO/Smac antibody/GMab

Cat No.	Species	Antibody Name	Format	Detail
GM-Tg-hg-IP0216-Ab	Human	Anti-Human DIABLO/Smac monoclonal antibody	mab	Detail
GM-Tg-rg-IP0216-Ab	Rat	Anti-Rat DIABLO/Smac monoclonal antibody	mab	Detail
GM-Tg-mg-IP0216-Ab	Mouse	Anti-Mouse DIABLO/Smac monoclonal antibody	mab	Detail
GM-Tg-cynog-IP0216-Ab	Cynomolgus/Rhesus macaque	Anti-Cynomolgus/Rhesus macaque DIABLO/Smac monoclonal antibody	mab	Detail
GM-Tg-felg-IP0216-Ab	Cat/Feline	Anti-Cat/Feline DIABLO/Smac monoclonal antibody	mab	Detail
GM-Tg-cang-IP0216-Ab	Dog/Canine	Anti-Dog/Canine DIABLO/Smac monoclonal antibody	mab	Detail
GM-Tg-bovg-IP0216-Ab	Bovines/Cattle	Anti-Bovines/Cattle DIABLO/Smac monoclonal antibody	mab	Detail
GM-Tg-equg-IP0216-Ab	Equine/Horse	Anti-Equine/Horse DIABLO/Smac monoclonal antibody	mab	Detail

DIABLO/Smac recombinant protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-IP0216-Ag	Human	Human DIABLO/Smac recombinant protein	Mammalian cell	Detail
GM-Tg-rg-IP0216-Ag	Rat	Rat DIABLO/Smac recombinant protein	Mammalian cell	Detail
GM-Tg-mg-IP0216-Ag	Mouse	Mouse DIABLO/Smac recombinant protein	Mammalian cell	Detail
GM-Tg-cynog-IP0216-Ag	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque DIABLO/Smac recombinant protein	Mammalian cell	Detail
GM-Tg-felg-IP0216-Ag	Cat/Feline	Cat/Feline DIABLO/Smac recombinant protein	Mammalian cell	Detail
GM-Tg-cang-IP0216-Ag	Dog/Canine	Dog/Canine DIABLO/Smac recombinant protein	Mammalian cell	Detail
GM-Tg-bovg-IP0216-Ag	Bovines/Cattle	Bovines/Cattle DIABLO/Smac recombinant protein	Mammalian cell	Detail
GM-Tg-equg-IP0216-Ag	Equine/Horse	Equine/Horse DIABLO/Smac recombinant protein	Mammalian cell	Detail