Explore PCSK7 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]
| Target ID |
GM-IP0192
|
| Target Name |
PCSK7
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
9159
|
| Gene ID |
100062727 (Equus caballus), 101086172 (Felis catus), 18554 (Mus musculus), 29606 (Rattus norvegicus) 479423 (Canis lupus familiaris), 515398 (Bos taurus), 697567 (Macaca mulatta), 9159 (Homo sapiens)
|
| Target Alternative Names |
LPC,Lymphoma proprotein convertase,PC7,PC8,PCSK7,Pcsk7,Prohormone convertase 7,Proprotein convertase 7 (PC7),Proprotein convertase 8 (PC8,Proprotein convertase subtilisin/kexin type 7,SPC7,Subtilisin/kexin-like protease PC7,hPC8)
|
| Uniprot Accession |
Q61139,Q62849,Q16549
|
| Protein Sub-location |
Introcelluar Protein
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000017980, ENSMUSG00000035382, ENSCAFG00845004009, ENSBTAG00000003052, ENSMMUG00000002061, ENSG00000160613
|
PCSK7 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9159 | Pre-made Human PCSK7/LPC/PC7 siRNA oligo Duplex | 9159 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29606 | Pre-made Rat Pcsk7/PC7 siRNA oligo Duplex | 29606 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18554 | Pre-made Mouse Pcsk7/PC7/SPC7 siRNA oligo Duplex | 18554 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697567 | Pre-made Cynomolgus/Rhesus macaque PCSK7 siRNA oligo Duplex | 697567 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086172 | Pre-made Cat/Feline PCSK7 siRNA oligo Duplex | 101086172 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479423 | Pre-made Dog/Canine PCSK7 siRNA oligo Duplex | 479423 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo515398 | Pre-made Bovines/Cattle PCSK7 siRNA oligo Duplex | 515398 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100062727 | Pre-made Equine/Horse PCSK7 siRNA oligo Duplex | 100062727 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PCSK7 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0192-Ab | Human | Anti-Human PCSK7 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP0192-Ab | Rat | Anti-Rat PCSK7 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP0192-Ab | Mouse | Anti-Mouse PCSK7 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP0192-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PCSK7 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP0192-Ab | Cat/Feline | Anti-Cat/Feline PCSK7 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP0192-Ab | Dog/Canine | Anti-Dog/Canine PCSK7 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP0192-Ab | Bovines/Cattle | Anti-Bovines/Cattle PCSK7 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP0192-Ab | Equine/Horse | Anti-Equine/Horse PCSK7 monoclonal antibody | mab | | Detail |
PCSK7 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0192-Ag | Human | Human PCSK7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0192-Ag | Rat | Rat PCSK7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0192-Ag | Mouse | Mouse PCSK7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0192-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PCSK7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0192-Ag | Cat/Feline | Cat/Feline PCSK7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0192-Ag | Dog/Canine | Dog/Canine PCSK7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0192-Ag | Bovines/Cattle | Bovines/Cattle PCSK7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0192-Ag | Equine/Horse | Equine/Horse PCSK7 recombinant protein | Mammalian cell | Detail |