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Target
sublocation: Introcelluar Protein.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
| Target ID |
GM-IP0187
|
| Target Name |
TAP1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6890
|
| Gene ID |
100060845 (Equus caballus), 101083591 (Felis catus), 21354 (Mus musculus), 24811 (Rattus norvegicus) 474866 (Canis lupus familiaris), 524959 (Bos taurus), 6890 (Homo sapiens), 717726 (Macaca mulatta)
|
| Target Alternative Names |
ABC17,ABCB2,APT1,ATP-binding cassette sub-family B member 2,Abcb2,Antigen peptide transporter 1,Cim,D6S114E,Ham-1,Ham1,MHC1D1,MTP1,PSF-1,PSF1,Peptide supply factor 1,Peptide transporter PSF1 (PSF-1),Peptide transporter TAP1,Peptide transporter involved in antigen processing 1,RING4,Really interesting new gene 4 protein (RING4),TAP,TAP1,TAP1*0102N,TAP1N,Tap-1,Tap1,Tap2,Y3
|
| Uniprot Accession |
P21958,P36370,Q03518
|
| Protein Sub-location |
Introcelluar Protein
|
| Disease |
cancer
|
| Disease from KEGG |
ABC transporters, Phagosome, Antigen processing and presentation, Human cytomegalovirus infection, Epstein-Barr virus infection
|
| Gene Ensembl |
ENSECAG00000022610, ENSMUSG00000037321, ENSCAFG00845018353, ENSBTAG00000008953, ENSG00000168394, ENSMMUG00000011301
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of TAP1 cDNA Clones/ORF Plasmid
TAP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6890 | Pre-made Human TAP1/APT1/PSF1 siRNA oligo Duplex | 6890 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24811 | Pre-made Rat Tap1/Cim/Tap2 siRNA oligo Duplex | 24811 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21354 | Pre-made Mouse Tap1/Y3/TAP siRNA oligo Duplex | 21354 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717726 | Pre-made Cynomolgus/Rhesus macaque TAP1 siRNA oligo Duplex | 717726 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101083591 | Pre-made Cat/Feline TAP1 siRNA oligo Duplex | 101083591 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo474866 | Pre-made Dog/Canine TAP1/APT1 siRNA oligo Duplex | 474866 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo524959 | Pre-made Bovines/Cattle TAP1 siRNA oligo Duplex | 524959 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060845 | Pre-made Equine/Horse TAP1 siRNA oligo Duplex | 100060845 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TAP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0187-Ab | Human | Anti-Human TAP1 monoclonal antibody | mab | | Detail |
| GM-Tg-rg-IP0187-Ab | Rat | Anti-Rat TAP1 monoclonal antibody | mab | | Detail |
| GM-Tg-mg-IP0187-Ab | Mouse | Anti-Mouse TAP1 monoclonal antibody | mab | | Detail |
| GM-Tg-cynog-IP0187-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TAP1 monoclonal antibody | mab | | Detail |
| GM-Tg-felg-IP0187-Ab | Cat/Feline | Anti-Cat/Feline TAP1 monoclonal antibody | mab | | Detail |
| GM-Tg-cang-IP0187-Ab | Dog/Canine | Anti-Dog/Canine TAP1 monoclonal antibody | mab | | Detail |
| GM-Tg-bovg-IP0187-Ab | Bovines/Cattle | Anti-Bovines/Cattle TAP1 monoclonal antibody | mab | | Detail |
| GM-Tg-equg-IP0187-Ab | Equine/Horse | Anti-Equine/Horse TAP1 monoclonal antibody | mab | | Detail |
TAP1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0187-Ag | Human | Human TAP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0187-Ag | Rat | Rat TAP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0187-Ag | Mouse | Mouse TAP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0187-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TAP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0187-Ag | Cat/Feline | Cat/Feline TAP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0187-Ag | Dog/Canine | Dog/Canine TAP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0187-Ag | Bovines/Cattle | Bovines/Cattle TAP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0187-Ag | Equine/Horse | Equine/Horse TAP1 recombinant protein | Mammalian cell | Detail |