Explore G6PC/G6PC1 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]
| Target ID |
GM-IP0145
|
| Target Name |
G6PC/G6PC1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2538
|
| Gene ID |
100052233 (Equus caballus), 14377 (Mus musculus), 2538 (Homo sapiens), 25634 (Rattus norvegicus) 403492 (Canis lupus familiaris), 538710 (Bos taurus), 712053 (Macaca mulatta), 723970 (Felis catus)
|
| Target Alternative Names |
G-6-Pase,G6PC,G6PC1,G6PT,G6Pase,G6Pase),G6pc,G6pc1,G6pt,GSD1,GSD1a,Glc-6-Pase,Glucose-6-phosphatase (G-6-Pase,Glucose-6-phosphatase alpha (G6Pase-alpha),Glucose-6-phosphatase catalytic subunit 1,Psme3
|
| Uniprot Accession |
P35576,P35575,P43428,O19133,Q29RU6,Q19KA1
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, FoxO signaling pathway, PI3K-Akt signaling pathway, Adipocytokine signaling pathway, Insulin resistance, Carbohydrate digestion and absorption
|
| Gene Ensembl |
ENSECAG00000000509, ENSMUSG00000078650, ENSG00000131482, ENSCAFG00845006712, ENSBTAG00000010184, ENSMMUG00000008087
|
Pre-made viral vector of G6PC/G6PC1 cDNA Clones/ORF Plasmid
G6PC/G6PC1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2538 | Pre-made Human G6PC1/G6PC/G6PT siRNA oligo Duplex | 2538 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25634 | Pre-made Rat G6pc1/G6pc/Psme3 siRNA oligo Duplex | 25634 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14377 | Pre-made Mouse G6pc1/G6pc/G6pt siRNA oligo Duplex | 14377 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo712053 | Pre-made Cynomolgus/Rhesus macaque G6PC1/G6PC siRNA oligo Duplex | 712053 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo723970 | Pre-made Cat/Feline G6PC1/G6PC/G6Pase siRNA oligo Duplex | 723970 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403492 | Pre-made Dog/Canine G6PC1/G6PC/G6Pase siRNA oligo Duplex | 403492 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538710 | Pre-made Bovines/Cattle G6PC1/G6PC siRNA oligo Duplex | 538710 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052233 | Pre-made Equine/Horse G6PC1/G6PC siRNA oligo Duplex | 100052233 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
G6PC/G6PC1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0145-Ab | Human | Anti-Human G6PC/G6PC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0145-Ab | Rat | Anti-Rat G6PC/G6PC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0145-Ab | Mouse | Anti-Mouse G6PC/G6PC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0145-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque G6PC/G6PC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0145-Ab | Cat/Feline | Anti-Cat/Feline G6PC/G6PC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0145-Ab | Dog/Canine | Anti-Dog/Canine G6PC/G6PC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0145-Ab | Bovines/Cattle | Anti-Bovines/Cattle G6PC/G6PC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0145-Ab | Equine/Horse | Anti-Equine/Horse G6PC/G6PC1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
G6PC/G6PC1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0145-Ag | Human | Human G6PC/G6PC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0145-Ag | Rat | Rat G6PC/G6PC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0145-Ag | Mouse | Mouse G6PC/G6PC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0145-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque G6PC/G6PC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0145-Ag | Cat/Feline | Cat/Feline G6PC/G6PC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0145-Ag | Dog/Canine | Dog/Canine G6PC/G6PC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0145-Ag | Bovines/Cattle | Bovines/Cattle G6PC/G6PC1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0145-Ag | Equine/Horse | Equine/Horse G6PC/G6PC1 recombinant protein | Mammalian cell | Detail |