Explore CFLAR/FLIP gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
| Target ID |
GM-IP0138
|
| Target Name |
CFLAR/FLIP
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8837
|
| Gene ID |
100068181 (Equus caballus), 100142680 (Felis catus), 117279 (Rattus norvegicus), 12633 (Mus musculus)
488471 (Canis lupus familiaris), 497199 (Bos taurus), 574234 (Macaca mulatta), 8837 (Homo sapiens)
|
| Target Alternative Names |
2310024N18Rik,A430105C05Rik,CASH,CASP8 and FADD-like apoptosis regulator,CASP8AP1,CFLAR,CLARP,Cash,Caspase homolog (CASH),Caspase-eight-related protein (Casper),Caspase-like apoptosis regulatory protein (CLARP),Casper,Cellular FLICE-like inhibitory protein (c-FLIP),Cflar,FADD-like antiapoptotic molecule 1 (FLAME-1),FLAME,FLAME-1,FLAME1,FLIP,Flip,Gm9845,I-FLICE,Inhibitor of FLICE (I-FLICE),MACH-related inducer of toxicity (MRIT),MRIT,Usurpin,c-FLIP,c-FLIPL,c-FLIPR,c-FLIPS,c-Flip,cFLIP
|
| Uniprot Accession |
O35732,O15519
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
NF-kappa B signaling pathway, Apoptosis, TNF signaling pathway, Chagas disease, Hepatitis C
|
| Gene Ensembl |
ENSECAG00000021300, ENSMUSG00000026031, ENSCAFG00845029893, ENSBTAG00000010998, ENSMMUG00000012310, ENSG00000003402
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CFLAR/FLIP cDNA Clones/ORF Plasmid
CFLAR/FLIP siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8837 | Pre-made Human CFLAR/CASH/FLIP siRNA oligo Duplex | 8837 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo117279 | Pre-made Rat Cflar/Flip siRNA oligo Duplex | 117279 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12633 | Pre-made Mouse Cflar/Cash/Flip siRNA oligo Duplex | 12633 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574234 | Pre-made Cynomolgus/Rhesus macaque CFLAR siRNA oligo Duplex | 574234 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100142680 | Pre-made Cat/Feline CFLAR/FLIP siRNA oligo Duplex | 100142680 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488471 | Pre-made Dog/Canine CFLAR siRNA oligo Duplex | 488471 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo497199 | Pre-made Bovines/Cattle CFLAR/FLIP siRNA oligo Duplex | 497199 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100068181 | Pre-made Equine/Horse CFLAR siRNA oligo Duplex | 100068181 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CFLAR/FLIP antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0138-Ab | Human | Anti-Human CFLAR/FLIP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0138-Ab | Rat | Anti-Rat CFLAR/FLIP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0138-Ab | Mouse | Anti-Mouse CFLAR/FLIP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0138-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CFLAR/FLIP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0138-Ab | Cat/Feline | Anti-Cat/Feline CFLAR/FLIP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0138-Ab | Dog/Canine | Anti-Dog/Canine CFLAR/FLIP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0138-Ab | Bovines/Cattle | Anti-Bovines/Cattle CFLAR/FLIP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0138-Ab | Equine/Horse | Anti-Equine/Horse CFLAR/FLIP monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CFLAR/FLIP recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0138-Ag | Human | Human CFLAR/FLIP recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0138-Ag | Rat | Rat CFLAR/FLIP recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0138-Ag | Mouse | Mouse CFLAR/FLIP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0138-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CFLAR/FLIP recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0138-Ag | Cat/Feline | Cat/Feline CFLAR/FLIP recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0138-Ag | Dog/Canine | Dog/Canine CFLAR/FLIP recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0138-Ag | Bovines/Cattle | Bovines/Cattle CFLAR/FLIP recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0138-Ag | Equine/Horse | Equine/Horse CFLAR/FLIP recombinant protein | Mammalian cell | Detail |
