Explore MKK7/MAP2K7 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
| Target ID |
GM-IP0114
|
| Target Name |
MKK7/MAP2K7
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5609
|
| Gene ID |
100147230 (Equus caballus), 101095157 (Felis catus), 26400 (Mus musculus), 363855 (Rattus norvegicus)
485004 (Canis lupus familiaris), 5609 (Homo sapiens), 710077 (Macaca mulatta), 787278 (Bos taurus)
|
| Target Alternative Names |
5930412N11Rik,Dual specificity mitogen-activated protein kinase kinase 7,JNK-activating kinase 2,JNKK,JNKK 2,JNKK 2),JNKK2,Jnkk2,MAP kinase kinase 7,MAP2K7,MAPK/ERK kinase 7 (MEK 7),MAPKK 7,MAPKK7,MEK,MEK 7,MKK7,Map2k7,Mapkk7,Mek7,Mkk7,PRKMK7,Prkmk7,SAPKK-4,SAPKK4,SAPKK4),Stress-activated protein kinase kinase 4 (SAPK kinase 4,c-Jun N-terminal kinase kinase 2 (JNK kinase 2,sek2
|
| Uniprot Accession |
Q8CE90,Q4KSH7,O14733
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
MAPK signaling pathway, ErbB signaling pathway, Protein processing in endoplasmic reticulum, Osteoclast differentiation, Tight junction, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, GnRH signaling pathway, Relaxin signaling pathway, Alcoholic liver disease, Alzheimer disease, Yersinia infection, Hepatitis B, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000009412, ENSMUSG00000002948, ENSCAFG00845028690, ENSG00000076984, ENSMMUG00000023303, ENSBTAG00000010639
|
Pre-made viral vector of MKK7/MAP2K7 cDNA Clones/ORF Plasmid
MKK7/MAP2K7 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5609 | Pre-made Human MAP2K7/MEK/MKK7 siRNA oligo Duplex | 5609 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo363855 | Pre-made Rat Map2k7/JNKK/Mek7 siRNA oligo Duplex | 363855 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo26400 | Pre-made Mouse Map2k7/Mek7/Mkk7 siRNA oligo Duplex | 26400 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710077 | Pre-made Cynomolgus/Rhesus macaque MAP2K7 siRNA oligo Duplex | 710077 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095157 | Pre-made Cat/Feline MAP2K7 siRNA oligo Duplex | 101095157 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485004 | Pre-made Dog/Canine MAP2K7 siRNA oligo Duplex | 485004 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo787278 | Pre-made Bovines/Cattle MAP2K7 siRNA oligo Duplex | 787278 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100147230 | Pre-made Equine/Horse MAP2K7 siRNA oligo Duplex | 100147230 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MKK7/MAP2K7 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0114-Ab | Human | Anti-Human MKK7/MAP2K7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0114-Ab | Rat | Anti-Rat MKK7/MAP2K7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0114-Ab | Mouse | Anti-Mouse MKK7/MAP2K7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0114-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MKK7/MAP2K7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0114-Ab | Cat/Feline | Anti-Cat/Feline MKK7/MAP2K7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0114-Ab | Dog/Canine | Anti-Dog/Canine MKK7/MAP2K7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0114-Ab | Bovines/Cattle | Anti-Bovines/Cattle MKK7/MAP2K7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0114-Ab | Equine/Horse | Anti-Equine/Horse MKK7/MAP2K7 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MKK7/MAP2K7 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0114-Ag | Human | Human MKK7/MAP2K7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0114-Ag | Rat | Rat MKK7/MAP2K7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0114-Ag | Mouse | Mouse MKK7/MAP2K7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0114-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MKK7/MAP2K7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0114-Ag | Cat/Feline | Cat/Feline MKK7/MAP2K7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0114-Ag | Dog/Canine | Dog/Canine MKK7/MAP2K7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0114-Ag | Bovines/Cattle | Bovines/Cattle MKK7/MAP2K7 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0114-Ag | Equine/Horse | Equine/Horse MKK7/MAP2K7 recombinant protein | Mammalian cell | Detail |
