Explore MAPKAPK5 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
| Target ID |
GM-IP0100
|
| Target Name |
MAPKAPK5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8550
|
| Gene ID |
100057579 (Equus caballus), 101082699 (Felis catus), 17165 (Mus musculus), 477480 (Canis lupus familiaris)
498183 (Rattus norvegicus), 535625 (Bos taurus), 713521 (Macaca mulatta), 8550 (Homo sapiens)
|
| Target Alternative Names |
MAP kinase-activated protein kinase 5,MAPK-activated protein kinase 5,MAPKAP kinase 5,MAPKAP-K5,MAPKAPK-5,MAPKAPK5,MK-5,MK5,Mapkapk5,NCFD,PRAK,p38-regulated/activated protein kinase (PRAK)
|
| Uniprot Accession |
O54992,Q8IW41
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
MAPK signaling pathway
|
| Gene Ensembl |
ENSECAG00000010001, ENSMUSG00000029454, ENSCAFG00845019639, ENSBTAG00000009346, ENSMMUG00000022353, ENSG00000089022
|
| Target Classification |
Kinase
|
Pre-made viral vector of MAPKAPK5 cDNA Clones/ORF Plasmid
MAPKAPK5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8550 | Pre-made Human MAPKAPK5/MK5/MK-5 siRNA oligo Duplex | 8550 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo498183 | Pre-made Rat Mapkapk5 siRNA oligo Duplex | 498183 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17165 | Pre-made Mouse Mapkapk5/MK5/PRAK siRNA oligo Duplex | 17165 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo713521 | Pre-made Cynomolgus/Rhesus macaque MAPKAPK5 siRNA oligo Duplex | 713521 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082699 | Pre-made Cat/Feline MAPKAPK5 siRNA oligo Duplex | 101082699 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477480 | Pre-made Dog/Canine MAPKAPK5 siRNA oligo Duplex | 477480 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo535625 | Pre-made Bovines/Cattle MAPKAPK5 siRNA oligo Duplex | 535625 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057579 | Pre-made Equine/Horse MAPKAPK5 siRNA oligo Duplex | 100057579 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MAPKAPK5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0100-Ab | Human | Anti-Human MAPKAPK5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0100-Ab | Rat | Anti-Rat MAPKAPK5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0100-Ab | Mouse | Anti-Mouse MAPKAPK5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0100-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MAPKAPK5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0100-Ab | Cat/Feline | Anti-Cat/Feline MAPKAPK5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0100-Ab | Dog/Canine | Anti-Dog/Canine MAPKAPK5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0100-Ab | Bovines/Cattle | Anti-Bovines/Cattle MAPKAPK5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0100-Ab | Equine/Horse | Anti-Equine/Horse MAPKAPK5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MAPKAPK5 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0100-Ag | Human | Human MAPKAPK5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0100-Ag | Rat | Rat MAPKAPK5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0100-Ag | Mouse | Mouse MAPKAPK5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0100-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MAPKAPK5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0100-Ag | Cat/Feline | Cat/Feline MAPKAPK5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0100-Ag | Dog/Canine | Dog/Canine MAPKAPK5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0100-Ag | Bovines/Cattle | Bovines/Cattle MAPKAPK5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0100-Ag | Equine/Horse | Equine/Horse MAPKAPK5 recombinant protein | Mammalian cell | Detail |
