Explore B7-H3/CD276 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
| Target ID |
GM-IP0069
|
| Target Name |
B7-H3/CD276
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
80381
|
| Gene ID |
100052046 (Equus caballus), 101087927 (Felis catus), 102657 (Mus musculus), 315716 (Rattus norvegicus)
487638 (Canis lupus familiaris), 508656 (Bos taurus), 699877 (Macaca mulatta), 80381 (Homo sapiens)
|
| Target Alternative Names |
4Ig-B7-H3,6030411F23Rik,B7 homolog 3 (B7-H3),B7-H3,B7H3,B7RP-2,B7h3,CD276,CD276 antigen,Cd276,Costimulatory molecule
|
| Uniprot Accession |
Q8VE98,Q7TPB4,Q5ZPR3
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Cell adhesion molecules
|
| Gene Ensembl |
ENSECAG00000004386, ENSMUSG00000035914, ENSBTAG00000019734, ENSMMUG00000005448, ENSG00000103855
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of B7-H3/CD276 cDNA Clones/ORF Plasmid
B7-H3/CD276 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo80381 | Pre-made Human CD276/B7H3/B7-H3 siRNA oligo Duplex | 80381 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo315716 | Pre-made Rat Cd276/B7h3/B7RP-2 siRNA oligo Duplex | 315716 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102657 | Pre-made Mouse Cd276/B7h3/B7-H3 siRNA oligo Duplex | 102657 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699877 | Pre-made Cynomolgus/Rhesus macaque CD276 siRNA oligo Duplex | 699877 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087927 | Pre-made Cat/Feline CD276 siRNA oligo Duplex | 101087927 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487638 | Pre-made Dog/Canine CD276 siRNA oligo Duplex | 487638 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo508656 | Pre-made Bovines/Cattle CD276 siRNA oligo Duplex | 508656 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052046 | Pre-made Equine/Horse CD276 siRNA oligo Duplex | 100052046 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
B7-H3/CD276 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0069-Ab | Human | Anti-Human B7-H3/CD276 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0069-Ab | Rat | Anti-Rat B7-H3/CD276 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0069-Ab | Mouse | Anti-Mouse B7-H3/CD276 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0069-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque B7-H3/CD276 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0069-Ab | Cat/Feline | Anti-Cat/Feline B7-H3/CD276 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0069-Ab | Dog/Canine | Anti-Dog/Canine B7-H3/CD276 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0069-Ab | Bovines/Cattle | Anti-Bovines/Cattle B7-H3/CD276 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0069-Ab | Equine/Horse | Anti-Equine/Horse B7-H3/CD276 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
B7-H3/CD276 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0069-Ag | Human | Human B7-H3/CD276 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0069-Ag | Rat | Rat B7-H3/CD276 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0069-Ag | Mouse | Mouse B7-H3/CD276 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0069-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque B7-H3/CD276 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0069-Ag | Cat/Feline | Cat/Feline B7-H3/CD276 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0069-Ag | Dog/Canine | Dog/Canine B7-H3/CD276 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0069-Ag | Bovines/Cattle | Bovines/Cattle B7-H3/CD276 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0069-Ag | Equine/Horse | Equine/Horse B7-H3/CD276 recombinant protein | Mammalian cell | Detail |
