HIF-1 alpha/HIF1A/HIF-1A Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore HIF-1 alpha/HIF1A/HIF-1A gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

Target ID	GM-IP0067
Target Name	HIF-1 alpha/HIF1A/HIF-1A
Gene Group ldentifer （Target Gene ID in Homo species)	3091
Gene ID	100061166 (Equus caballus), 101083686 (Felis catus), 15251 (Mus musculus), 281814 (Bos taurus) 29560 (Rattus norvegicus), 3091 (Homo sapiens), 480348 (Canis lupus familiaris), 704678 (Macaca mulatta)
Target Alternative Names	ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,Class E basic helix-loop-helix protein 78 (bHLHe78),HIF-1 alpha,HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,HIF1-alpha,HIF1A,HIF1alpha,Hif1a,Hypoxia-inducible factor 1-alpha,MOP1,Member of PAS protein 1,PAS domain-containing protein 8,PASD8,bHLHe78
Uniprot Accession	Q61221,Q9XTA5,O35800,Q16665
Protein Sub-location	Introcelluar Protein
Category	Therapeutics Target
Disease	cancer
Disease from KEGG	HIF-1 signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ensembl	ENSECAG00000015597, ENSMUSG00000021109, ENSBTAG00000020935, ENSG00000100644, ENSCAFG00845023223, ENSMMUG00000021002
Target Classification	Tumor-associated antigen (TAA)

Pre-made viral vector of HIF-1 alpha/HIF1A/HIF-1A cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLV000323	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus plasmid	NM_001530.3	3091	Human	Lentivirus plasmid	Firefly luciferase	Null	CMV	Detail
pGMPC000131	Human HIF1A/bHLHe78/HIF-1-alpha Mammalian (Non-Viral Vector) plasmid	NM_001243084.1	3091	Human	Mammalian (Non-Viral Vector) plasmid	EGFP	Null	EF1	Detail
vGMAD001239	Human HIF1A/bHLHe78/HIF-1-alpha Adenovirus particle	NM_001530.4	3091	Human	Adenovirus particle	Null	3xflag (C-Terminal)	CMV	Detail
vGMAD001152	Human HIF1A/bHLHe78/HIF-1-alpha Adenovirus particle	NM_001530.3	3091	Human	Adenovirus particle	mCherry	3xflag (C-Terminal)	EF1	Detail
vGMAD000098	Human HIF1A/bHLHe78/HIF-1-alpha Adenovirus particle	NM_001243084.1	3091	Human	Adenovirus particle	GFP	3xflag (C-Terminal)	EF1	Detail
vGMLV002302	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus particle	nm_001530.4	3091	Human	Lentivirus particle	Firefly luciferase	Null	CMV	Detail
vGMLV001313	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus particle	NM_001530.4	3091	Human	Lentivirus particle	Firefly luciferase	3xflag (C-Terminal)	CMV	Detail
vGMLV000727	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus particle	NM_001530.3	3091	Human	Lentivirus particle	Null	3xflag (C-Terminal)	CMV	Detail
vGMLV000495	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus particle	NM_001530.3	3091	Human	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLV000323	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus particle	NM_001530.3	3091	Human	Lentivirus particle	Firefly luciferase	Null	CMV	Detail
pGMPC001665	Human HIF1A/bHLHe78/HIF-1-alpha Mammalian (Non-Viral Vector) plasmid	NM_001530.4	3091	Human	Mammalian (Non-Viral Vector) plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMPC001302	Human HIF1A/bHLHe78/HIF-1-alpha Mammalian (Non-Viral Vector) plasmid	NM_001530.4	3091	Human	Mammalian (Non-Viral Vector) plasmid	Null	Null	CMV	Detail
pGMPC001171	Human HIF1A/bHLHe78/HIF-1-alpha Mammalian (Non-Viral Vector) plasmid	NM_001530.4	3091	Human	Mammalian (Non-Viral Vector) plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMLV000495	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus plasmid	NM_001530.3	3091	Human	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMPC000326	Human HIF1A/bHLHe78/HIF-1-alpha Mammalian (Non-Viral Vector) plasmid	NM_001530.3	3091	Human	Mammalian (Non-Viral Vector) plasmid	Null	Null	CMV	Detail
pGMPC001081	Human HIF1A/bHLHe78/HIF-1-alpha Mammalian (Non-Viral Vector) plasmid	NM_001530.4	3091	Human	Mammalian (Non-Viral Vector) plasmid	Null	HA (C-Terminal)	CMV	Detail
pGMAD000098	Human HIF1A/bHLHe78/HIF-1-alpha Adenovirus plasmid	NM_001243084.1	3091	Human	Adenovirus plasmid	GFP	3xflag (C-Terminal)	EF1	Detail
pGMAD001239	Human HIF1A/bHLHe78/HIF-1-alpha Adenovirus plasmid	NM_001530.4	3091	Human	Adenovirus plasmid	Null	3xflag (C-Terminal)	CMV	Detail
pGMLV000727	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus plasmid	NM_001530.3	3091	Human	Lentivirus plasmid	Null	3xflag (C-Terminal)	CMV	Detail
pGMLV001313	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus plasmid	NM_001530.4	3091	Human	Lentivirus plasmid	Firefly luciferase	3xflag (C-Terminal)	CMV	Detail
pGMLV002302	Human HIF1A/bHLHe78/HIF-1-alpha Lentivirus plasmid	nm_001530.4	3091	Human	Lentivirus plasmid	Firefly luciferase	Null	CMV	Detail
pGMAD001152	Human HIF1A/bHLHe78/HIF-1-alpha Adenovirus plasmid	NM_001530.3	3091	Human	Adenovirus plasmid	mCherry	3xflag (C-Terminal)	EF1	Detail
vGMAAV000498	Rat Hif1a/MOP1 Adeno-associate virus(AAV) particle	NM_024359.1	29560	Rat	Adeno-associate virus(AAV) particle	Null	3xflag (C-Terminal)	cTNT	Detail
vGMAAV000349	Rat Hif1a/MOP1 Adeno-associate virus(AAV) particle	NM_024359.1	29560	Rat	Adeno-associate virus(AAV) particle	Null	3xflag (C-Terminal)	CMV	Detail
vGMAD000326	Rat Hif1a/MOP1 Adenovirus particle	NM_024359.1	29560	Rat	Adenovirus particle	Null	3xflag (C-Terminal)	CMV	Detail
vGMLV002724	Rat Hif1a/HIF1-alpha/MOP1 Lentivirus particle	NM_024359.2	29560	Rat	Lentivirus particle	ZsGreen	Null	CMV	Detail
pGMLV002724	Rat Hif1a/HIF1-alpha/MOP1 Lentivirus plasmid	NM_024359.2	29560	Rat	Lentivirus plasmid	ZsGreen	Null	CMV	Detail
pGMAD000326	Rat Hif1a/MOP1 Adenovirus plasmid	NM_024359.1	29560	Rat	Adenovirus plasmid	Null	3xflag (C-Terminal)	CMV	Detail
pGMPC004719	Rat Hif1a/HIF1-alpha/MOP1 Mammalian (Non-Viral Vector) plasmid	NM_024359.2	29560	Rat	Mammalian (Non-Viral Vector) plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMAAV000498	Rat Hif1a/MOP1 Adeno-associate virus(AAV) plasmid	NM_024359.1	29560	Rat	Adeno-associate virus(AAV) plasmid	Null	3xflag (C-Terminal)	cTNT	Detail
pGMAAV000349	Rat Hif1a/MOP1 Adeno-associate virus(AAV) plasmid	NM_024359.1	29560	Rat	Adeno-associate virus(AAV) plasmid	Null	3xflag (C-Terminal)	CMV	Detail
pGMPC000128	Rat Hif1a/MOP1 Mammalian (Non-Viral Vector) plasmid	NM_024359.1	29560	Rat	Mammalian (Non-Viral Vector) plasmid	Null	Null	CMV	Detail
pGMPC000669	Rat Hif1a/MOP1 Mammalian (Non-Viral Vector) plasmid	NM_024359.1	29560	Rat	Mammalian (Non-Viral Vector) plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMPC000408	Rat Hif1a/MOP1 Mammalian (Non-Viral Vector) plasmid	NM_024359.1	29560	Rat	Mammalian (Non-Viral Vector) plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
pGMPC001635	Mouse Hif1a/bHLHe78/HIF-1-alpha Mammalian (Non-Viral Vector) plasmid	NM_010431.2	15251	Mouse	Mammalian (Non-Viral Vector) plasmid	ZsGreen	Null	CMV	Detail
vGMAAV000764	Mouse Hif1a/AA959795/bHLHe7 Adeno-associate virus(AAV) particle	NM_010431.2	15251	Mouse	Adeno-associate virus(AAV) particle	Null	Null	TBG	Detail
pGMLPm004780	Mouse Hif1a/AA959795/bHLHe78 Lentivirus plasmid	NM_010431.2	15251	Mouse	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMAD001696	Mouse Hif1a/bHLHe78/HIF-1-alpha Adenovirus particle	NM_010431.2	15251	Mouse	Adenovirus particle	EGFP	3xflag (C-Terminal)	EF1	Detail
vGMAD001428	Mouse Hif1a/bHLHe78/HIF-1-alpha Adenovirus particle	NM_010431.2	15251	Mouse	Adenovirus particle	EGFP	3xflag (C-Terminal)	EF1	Detail
vGMAD001267	Mouse Hif1a/AA959795/bHLHe78 Adenovirus particle	NM_010431.2	15251	Mouse	Adenovirus particle	Null	3xflag (C-Terminal)	CMV	Detail
pGMAD001696	Mouse Hif1a/bHLHe78/HIF-1-alpha Adenovirus plasmid	NM_010431.2	15251	Mouse	Adenovirus plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMAD001267	Mouse Hif1a/AA959795/bHLHe78 Adenovirus plasmid	NM_010431.2	15251	Mouse	Adenovirus plasmid	Null	3xflag (C-Terminal)	CMV	Detail
pGMLV001979	Mouse Hif1a/AA959795/bHLHe78 Lentivirus plasmid	NM_010431.2	15251	Mouse	Lentivirus plasmid	Null	3xflag (C-Terminal)	CMV	Detail
pGMPC000957	Mouse Hif1a/AA959795/bHLHe78 Mammalian (Non-Viral Vector) plasmid	NM_010431	15251	Mouse	Mammalian (Non-Viral Vector) plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMLV001979	Mouse Hif1a/AA959795/bHLHe78 Lentivirus particle	NM_010431.2	15251	Mouse	Lentivirus particle	Null	3xflag (C-Terminal)	CMV	Detail
pGMAD001428	Mouse Hif1a/bHLHe78/HIF-1-alpha Adenovirus plasmid	NM_010431.2	15251	Mouse	Adenovirus plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMAAV000764	Mouse Hif1a/AA959795/bHLHe7 Adeno-associate virus(AAV) plasmid	NM_010431.2	15251	Mouse	Adeno-associate virus(AAV) plasmid	Null	Null	TBG	Detail
vGMLPm004780	Mouse Hif1a/AA959795/bHLHe78 Lentivirus particle	NM_010431.2	15251	Mouse	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMAD001350	Cattle HIF1A Adenovirus particle	NM_174339.3	281814	Cattle	Adenovirus particle	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMAD001350	Cattle HIF1A Adenovirus plasmid	NM_174339.3	281814	Cattle	Adenovirus plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail

HIF-1 alpha/HIF1A/HIF-1A siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo3091	Pre-made Human HIF1A/HIF1/MOP1 siRNA oligo Duplex	3091	Human	In-vitro grade; in-vivo grade	Detail
pGMoligo29560	Pre-made Rat Hif1a/MOP1/HIF1-alpha siRNA oligo Duplex	29560	Rat	In-vitro grade; in-vivo grade	Detail
pGMoligo15251	Pre-made Mouse Hif1a/MOP1/bHLHe78 siRNA oligo Duplex	15251	Mouse	In-vitro grade; in-vivo grade	Detail
pGMoligo704678	Pre-made Cynomolgus/Rhesus macaque HIF1A siRNA oligo Duplex	704678	Cynomolgus/Rhesus macaque	In-vitro grade; in-vivo grade	Detail
pGMoligo101083686	Pre-made Cat/Feline HIF1A siRNA oligo Duplex	101083686	Cat/Feline	In-vitro grade; in-vivo grade	Detail
pGMoligo480348	Pre-made Dog/Canine HIF1A siRNA oligo Duplex	480348	Dog/Canine	In-vitro grade; in-vivo grade	Detail
pGMoligo281814	Pre-made Bovines/Cattle HIF1A siRNA oligo Duplex	281814	Bovines/Cattle	In-vitro grade; in-vivo grade	Detail
pGMoligo100061166	Pre-made Equine/Horse HIF1A/HIF1-alpha siRNA oligo Duplex	100061166	Equine/Horse	In-vitro grade; in-vivo grade	Detail

HIF-1 alpha/HIF1A/HIF-1A antibody/GMab

Cat No.	Species	Antibody Name	Format	Classified by tag	Detail
GM-Tg-hg-IP0067-Ab	Human	Anti-Human HIF-1 alpha/HIF1A/HIF-1A monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-rg-IP0067-Ab	Rat	Anti-Rat HIF-1 alpha/HIF1A/HIF-1A monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-mg-IP0067-Ab	Mouse	Anti-Mouse HIF-1 alpha/HIF1A/HIF-1A monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-cynog-IP0067-Ab	Cynomolgus/Rhesus macaque	Anti-Cynomolgus/Rhesus macaque HIF-1 alpha/HIF1A/HIF-1A monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-felg-IP0067-Ab	Cat/Feline	Anti-Cat/Feline HIF-1 alpha/HIF1A/HIF-1A monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-cang-IP0067-Ab	Dog/Canine	Anti-Dog/Canine HIF-1 alpha/HIF1A/HIF-1A monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-bovg-IP0067-Ab	Bovines/Cattle	Anti-Bovines/Cattle HIF-1 alpha/HIF1A/HIF-1A monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-equg-IP0067-Ab	Equine/Horse	Anti-Equine/Horse HIF-1 alpha/HIF1A/HIF-1A monoclonal antibody	mab	Therapeutics Target antibody	Detail

HIF-1 alpha/HIF1A/HIF-1A recombinant protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-IP0067-Ag	Human	Human HIF-1 alpha/HIF1A/HIF-1A recombinant protein	Mammalian cell	Detail
GM-Tg-rg-IP0067-Ag	Rat	Rat HIF-1 alpha/HIF1A/HIF-1A recombinant protein	Mammalian cell	Detail
GM-Tg-mg-IP0067-Ag	Mouse	Mouse HIF-1 alpha/HIF1A/HIF-1A recombinant protein	Mammalian cell	Detail
GM-Tg-cynog-IP0067-Ag	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque HIF-1 alpha/HIF1A/HIF-1A recombinant protein	Mammalian cell	Detail
GM-Tg-felg-IP0067-Ag	Cat/Feline	Cat/Feline HIF-1 alpha/HIF1A/HIF-1A recombinant protein	Mammalian cell	Detail
GM-Tg-cang-IP0067-Ag	Dog/Canine	Dog/Canine HIF-1 alpha/HIF1A/HIF-1A recombinant protein	Mammalian cell	Detail
GM-Tg-bovg-IP0067-Ag	Bovines/Cattle	Bovines/Cattle HIF-1 alpha/HIF1A/HIF-1A recombinant protein	Mammalian cell	Detail
GM-Tg-equg-IP0067-Ag	Equine/Horse	Equine/Horse HIF-1 alpha/HIF1A/HIF-1A recombinant protein	Mammalian cell	Detail