Human HIF1A/bHLHe78/HIF-1-alpha ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_001530.4)

Cat. No.: pGMPC001081
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human HIF1A/bHLHe78/HIF-1-alpha Non-Viral expression plasmid (overexpression vector) for mouse HIF1A overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC001081
Gene Name HIF1A
Accession Number NM_001530.4
Gene ID 3091
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 2481 bp
Gene Alias bHLHe78,HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,MOP1,PASD8
Fluorescent Reporter Null
Mammalian Cell Selection Null
Fusion Tag HA (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACTGATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAACGAAAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCTGAAACGCCAAAGCCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCAAATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGTCCTTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCCAGTGAATATTGTTTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTTGCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAGATGTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTGTCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACAGTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACCACTGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAAATATTGATTGCATCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGAGATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGTCAAAGAACTACAGTTCCTGAGGAAGAACTAAATCCAAAGATACTAGCTTTGCAGAATGCTCAGAGAAAGCGAAAAATGGAACATGATGGTTCACTTTTTCAAGCAGTAGGAATTGGAACATTATTACAGCAGCCAGACGATCATGCAGCTACTACATCACTTTCTTGGAAACGTGTAAAAGGATGCAAATCTAGTGAACAGAATGGAATGGAGCAAAAGACAATTATTTTAATACCCTCTGATTTAGCATGTAGACTGCTGGGGCAATCAATGGATGAAAGTGGATTACCACAGCTGACCAGTTATGATTGTGAAGTTAATGCTCCTATACAAGGCAGCAGAAACCTACTGCAGGGTGAAGAATTACTCAGAGCTTTGGATCAAGTTAACTGA
ORF Protein Sequence MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-IP0067-Ab Anti-HIF-1A monoclonal antibody
    Target Antigen GM-Tg-g-IP0067-Ag HIF-1A/HIF1A protein
    ORF Viral Vector pGMLV000323 Human HIF1A Lentivirus plasmid
    ORF Viral Vector pGMLV000495 Human HIF1A Lentivirus plasmid
    ORF Viral Vector pGMLV000727 Human HIF1A Lentivirus plasmid
    ORF Viral Vector pGMLV001313 Human HIF1A Lentivirus plasmid
    ORF Viral Vector pGMLV002302 Human HIF1A Lentivirus plasmid
    ORF Viral Vector pGMAD000098 Human HIF1A Adenovirus plasmid
    ORF Viral Vector pGMAD001152 Human HIF1A Adenovirus plasmid
    ORF Viral Vector pGMAD001239 Human HIF1A Adenovirus plasmid
    ORF Viral Vector pGMPC000131 Human HIF1A Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC000326 Human HIF1A Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001081 Human HIF1A Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001171 Human HIF1A Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001302 Human HIF1A Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001665 Human HIF1A Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV000323 Human HIF1A Lentivirus particle
    ORF Viral Vector vGMLV000495 Human HIF1A Lentivirus particle
    ORF Viral Vector vGMLV000727 Human HIF1A Lentivirus particle
    ORF Viral Vector vGMLV001313 Human HIF1A Lentivirus particle
    ORF Viral Vector vGMLV002302 Human HIF1A Lentivirus particle
    ORF Viral Vector vGMAD000098 Human HIF1A Adenovirus particle
    ORF Viral Vector vGMAD001152 Human HIF1A Adenovirus particle
    ORF Viral Vector vGMAD001239 Human HIF1A Adenovirus particle


    Target information

    Target ID GM-IP0067
    Target Name HIF-1 alpha/HIF1A/HIF-1A
    Gene Group Identifier
    （Target Gene ID in Homo species)         		3091
    Gene ID 100061166 (Equus caballus), 101083686 (Felis catus), 15251 (Mus musculus), 281814 (Bos taurus)
    29560 (Rattus norvegicus), 3091 (Homo sapiens), 480348 (Canis lupus familiaris), 704678 (Macaca mulatta)
    Gene Symbols & Synonyms HIF1A,Hif1a,HIF1-alpha,MOP1,bHLHe78,HIF1alpha,HIF-1-alpha,HIF1,PASD8,HIF-1A,HIF-1alpha,HIF1-ALPHA
    Target Alternative Names HIF-1 alpha, HIF1A, HIF-1A,Hypoxia-inducible factor 1-alpha,HIF-1-alpha, HIF1-alpha,ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78 (bHLHe78), Member of PAS protein 1, PAS domain-containing protein 8,HIF1,MOP1,PASD8,HIF-1A,bHLHe78,HIF-1alpha,HIF1-ALPHA,HIF-1-alpha
    Uniprot Accession O35800,Q16665,Q61221,Q9XTA5
    Additional SwissProt Accessions: Q61221,Q9XTA5,O35800,Q16665
    Uniprot Entry Name
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease cancer
    Disease from KEGG HIF-1 signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer
    Gene Ensembl ENSECAG00000015597, ENSMUSG00000021109, ENSBTAG00000020935, ENSG00000100644, ENSCAFG00845023223, ENSMMUG00000021002
    Target Classification Tumor-associated antigen (TAA)


    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.