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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008]
Target ID |
GM-IP0029
|
Target Name |
FANCA
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2175
|
Gene ID |
100052495 (Equus caballus), 101081431 (Felis catus), 14087 (Mus musculus), 2175 (Homo sapiens) 361435 (Rattus norvegicus), 608713 (Canis lupus familiaris), 618375 (Bos taurus), 721746 (Macaca mulatta)
|
Target Alternative Names |
FA,FA-H,FA1,FAA,FACA,FAH,FANCA,FANCH,Fanca,Fanconi anemia group A protein,Protein FACA,ZNF276
|
Uniprot Accession |
Q9JL70,O15360
|
Uniprot Entry Name |
|
Protein Sub-location |
Introcelluar Protein
|
Category |
Therapeutics Target
|
Disease |
cancer
|
Disease from KEGG |
|
Gene Ensembl |
ENSECAG00000024214, ENSMUSG00000032815, ENSG00000187741, ENSCAFG00845001750, ENSBTAG00000001906, ENSMMUG00000029067
|
Target Classification |
Tumor-associated antigen (TAA)
|
FANCA siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo2175 | Pre-made Human FANCA/FA/FA1 siRNA oligo Duplex | 2175 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo361435 | Pre-made Rat Fanca siRNA oligo Duplex | 361435 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo14087 | Pre-made Mouse Fanca/FACA siRNA oligo Duplex | 14087 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo721746 | Pre-made Cynomolgus/Rhesus macaque FANCA/ZNF276 siRNA oligo Duplex | 721746 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101081431 | Pre-made Cat/Feline FANCA siRNA oligo Duplex | 101081431 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo608713 | Pre-made Dog/Canine FANCA siRNA oligo Duplex | 608713 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo618375 | Pre-made Bovines/Cattle FANCA siRNA oligo Duplex | 618375 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100052495 | Pre-made Equine/Horse FANCA siRNA oligo Duplex | 100052495 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FANCA antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-IP0029-Ab | Human | Anti-Human FANCA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-rg-IP0029-Ab | Rat | Anti-Rat FANCA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-mg-IP0029-Ab | Mouse | Anti-Mouse FANCA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cynog-IP0029-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FANCA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-felg-IP0029-Ab | Cat/Feline | Anti-Cat/Feline FANCA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-cang-IP0029-Ab | Dog/Canine | Anti-Dog/Canine FANCA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-bovg-IP0029-Ab | Bovines/Cattle | Anti-Bovines/Cattle FANCA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
GM-Tg-equg-IP0029-Ab | Equine/Horse | Anti-Equine/Horse FANCA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
FANCA recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-IP0029-Ag | Human | Human FANCA recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-IP0029-Ag | Rat | Rat FANCA recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-IP0029-Ag | Mouse | Mouse FANCA recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-IP0029-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FANCA recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-IP0029-Ag | Cat/Feline | Cat/Feline FANCA recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-IP0029-Ag | Dog/Canine | Dog/Canine FANCA recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-IP0029-Ag | Bovines/Cattle | Bovines/Cattle FANCA recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-IP0029-Ag | Equine/Horse | Equine/Horse FANCA recombinant protein | Mammalian cell | Detail |