Explore EIF2AK3/PERK gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
| Target ID |
GM-IP0003
|
| Target Name |
EIF2AK3/PERK
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9451
|
| Gene ID |
100066488 (Equus caballus), 101095973 (Felis catus), 13666 (Mus musculus), 29702 (Rattus norvegicus)
475756 (Canis lupus familiaris), 535820 (Bos taurus), 699575 (Macaca mulatta), 9451 (Homo sapiens)
|
| Target Alternative Names |
EIF2AK3,Eif2ak3,Eukaryotic translation initiation factor 2-alpha kinase 3,PEK,PERK,PRKR-like endoplasmic reticulum kinase,Pancreatic eIF2-alpha kinase (HsPEK),Pek,Perk,Protein tyrosine kinase EIF2AK3,WRS
|
| Uniprot Accession |
Q9Z2B5,Q9Z1Z1,A5D791,Q9NZJ5
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Protein processing in endoplasmic reticulum, Apoptosis, Alzheimer disease, Hepatitis C, Measles, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000020856, ENSMUSG00000031668, ENSCAFG00845012886, ENSBTAG00000000184, ENSMMUG00000009254, ENSG00000172071
|
| Target Classification |
Kinase, Checkpoint-Immuno Oncology
|
Pre-made viral vector of EIF2AK3/PERK cDNA Clones/ORF Plasmid
EIF2AK3/PERK siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9451 | Pre-made Human EIF2AK3/PEK/WRS siRNA oligo Duplex | 9451 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29702 | Pre-made Rat Eif2ak3/PEK siRNA oligo Duplex | 29702 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13666 | Pre-made Mouse Eif2ak3/Pek/Perk siRNA oligo Duplex | 13666 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699575 | Pre-made Cynomolgus/Rhesus macaque EIF2AK3 siRNA oligo Duplex | 699575 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095973 | Pre-made Cat/Feline EIF2AK3 siRNA oligo Duplex | 101095973 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475756 | Pre-made Dog/Canine EIF2AK3 siRNA oligo Duplex | 475756 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo535820 | Pre-made Bovines/Cattle EIF2AK3 siRNA oligo Duplex | 535820 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066488 | Pre-made Equine/Horse EIF2AK3 siRNA oligo Duplex | 100066488 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EIF2AK3/PERK antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0003-Ab | Human | Anti-Human EIF2AK3/PERK monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0003-Ab | Rat | Anti-Rat EIF2AK3/PERK monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0003-Ab | Mouse | Anti-Mouse EIF2AK3/PERK monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0003-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EIF2AK3/PERK monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0003-Ab | Cat/Feline | Anti-Cat/Feline EIF2AK3/PERK monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0003-Ab | Dog/Canine | Anti-Dog/Canine EIF2AK3/PERK monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0003-Ab | Bovines/Cattle | Anti-Bovines/Cattle EIF2AK3/PERK monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0003-Ab | Equine/Horse | Anti-Equine/Horse EIF2AK3/PERK monoclonal antibody | mab | Therapeutics Target antibody | Detail |
EIF2AK3/PERK recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0003-Ag | Human | Human EIF2AK3/PERK recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0003-Ag | Rat | Rat EIF2AK3/PERK recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0003-Ag | Mouse | Mouse EIF2AK3/PERK recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0003-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EIF2AK3/PERK recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0003-Ag | Cat/Feline | Cat/Feline EIF2AK3/PERK recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0003-Ag | Dog/Canine | Dog/Canine EIF2AK3/PERK recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0003-Ag | Bovines/Cattle | Bovines/Cattle EIF2AK3/PERK recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0003-Ag | Equine/Horse | Equine/Horse EIF2AK3/PERK recombinant protein | Mammalian cell | Detail |
