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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IO129
|
| Target Name |
RORC
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6097
|
| Gene ID |
100060134 (Equus caballus), 101082078 (Felis catus), 19885 (Mus musculus), 368158 (Rattus norvegicus) 483205 (Canis lupus familiaris), 527470 (Bos taurus), 6097 (Homo sapiens), 717052 (Macaca mulatta)
|
| Target Alternative Names |
IMD42,NR1F3,Nr1f3,Nuclear receptor ROR-gamma,Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,RORC,RORG,RORgamma,RZR-GAMMA,RZRG,Retinoid-related orphan receptor-gamma,Rorc,TOR,Thor
|
| Uniprot Accession |
P51450,P51449
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Th17 cell differentiation, Inflammatory bowel disease
|
| Gene Ensembl |
ENSECAG00000000918, ENSMUSG00000028150, ENSCAFG00845025144, ENSBTAG00000017405, ENSG00000143365, ENSMMUG00000012138
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of RORC cDNA Clones/ORF Plasmid
RORC siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6097 | Pre-made Human RORC/TOR/RORG siRNA oligo Duplex | 6097 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo368158 | Pre-made Rat Rorc siRNA oligo Duplex | 368158 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19885 | Pre-made Mouse Rorc/TOR/Thor siRNA oligo Duplex | 19885 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717052 | Pre-made Cynomolgus/Rhesus macaque RORC siRNA oligo Duplex | 717052 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082078 | Pre-made Cat/Feline RORC siRNA oligo Duplex | 101082078 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483205 | Pre-made Dog/Canine RORC siRNA oligo Duplex | 483205 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo527470 | Pre-made Bovines/Cattle RORC siRNA oligo Duplex | 527470 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060134 | Pre-made Equine/Horse RORC siRNA oligo Duplex | 100060134 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
RORC antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IO129-Ab | Human | Anti-Human RORC monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IO129-Ab | Rat | Anti-Rat RORC monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IO129-Ab | Mouse | Anti-Mouse RORC monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IO129-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque RORC monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IO129-Ab | Cat/Feline | Anti-Cat/Feline RORC monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IO129-Ab | Dog/Canine | Anti-Dog/Canine RORC monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IO129-Ab | Bovines/Cattle | Anti-Bovines/Cattle RORC monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IO129-Ab | Equine/Horse | Anti-Equine/Horse RORC monoclonal antibody | mab | Therapeutics Target antibody | Detail |
RORC recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IO129-Ag | Human | Human RORC recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IO129-Ag | Rat | Rat RORC recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IO129-Ag | Mouse | Mouse RORC recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IO129-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque RORC recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IO129-Ag | Cat/Feline | Cat/Feline RORC recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IO129-Ag | Dog/Canine | Dog/Canine RORC recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IO129-Ag | Bovines/Cattle | Bovines/Cattle RORC recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IO129-Ag | Equine/Horse | Equine/Horse RORC recombinant protein | Mammalian cell | Detail |