TPX2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of TPX2. The page also collects GeneMedi's different modalities and formats products for TPX2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TPX2 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; mitotic spindle; and nucleoplasm. Colocalizes with spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
| Target ID | GM-T92966 |
| Target Name | TPX2 |
| Gene ID | 22974,72119,311546,712961,477186,101096223,507226,100053648 |
| Gene Symbol and Synonyms | 2610005B21Rik,C20orf1,C20orf2,DIL-2,DIL2,FLS353,GD:C20orf1,HCA519,HCTP4,p100,REPP86,TPX2 |
| Uniprot Accession | Q9ULW0,A6H6Z7 |
| Uniprot Entry Name | TPX2_HUMAN,TPX2_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000088325 |
| Target Classification | Tumor-associated antigen (TAA) |
Pre-made anti-TPX2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-TPX2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TPX2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-TPX2 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species TPX2/ C20orf1/ C20orf2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TPX2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| TPX2 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made TPX2 viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMLP004422 | human TPX2 Lentivirus plasmid | NM_012112 | Human | Lentivirus plasmid | Detail |
| vGMLP004422 | human TPX2 Lentivirus particle | NM_012112 | Human | Lentivirus particle | Detail |
| pGMLPm003904 | mouse Tpx2 Lentivirus plasmid | NM_001141976 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm003904 | mouse Tpx2 Lentivirus particle | NM_001141976 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.