IL7R: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of IL7R. The page also collects GeneMedi's different modalities and formats products for IL7R in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the IL7R target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]
| Target ID | GM-T85025 |
| Target Name | IL7R |
| Gene ID | 3575,16197,294797,699869,612582,101100697,521554 |
| Gene Symbol and Synonyms | CD127,CDW127,IL-7R-alpha,IL-7Ralpha,IL7R,IL7RA,IL7Ralpha,ILRA,IMD104,lnc-IL7R,sIL-7R |
| Uniprot Accession | P16871 |
| Uniprot Entry Name | IL7RA_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000168685 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
Pre-made IL7R-specific INN-index biosimilar (antibody&conjugates)
Anti-IL7R therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
| Cat No. | Products Name (INN Index) | INN Name | Previous Name | Target | Format | Detail |
| GMP-Bios-INN-816 | Pre-Made Efineptakin Alfa Biosimilar, Fusion Protein targeting IL7R fused with human IGHG4 Fc (Fragment constant): Recombinant therapeutic protein targeting CD127/CDW127 | efineptakin alfa | IL7R | Fusion Protein | Detail | |
| GMP-Bios-ab-330 | Pre-Made Lusvertikimab biosimilar, Whole mAb, Anti-IL7R Antibody: Anti-CD127/CDW127 therapeutic antibody | Lusvertikimab | IL7R | Whole mAb | Detail |
Click to check more INN-indexed antibody & protein biosimilar
Pre-made anti-IL7R inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-IL7R benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-IL7R mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-IL7R monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Multi-species IL7RA/ IL7R/ CD127 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL7R VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| IL7R VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made IL7R viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMLP000737 | human IL7R Lentivirus plasmid | NM_002185 | Human | Lentivirus plasmid | Detail |
| vGMLP000737 | human IL7R Lentivirus particle | NM_002185 | Human | Lentivirus particle | Detail |
| pGMLPm001763 | mouse Il7r Lentivirus plasmid | NM_008372 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm001763 | mouse Il7r Lentivirus particle | NM_008372 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.