APOA4: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of APOA4. The page also collects GeneMedi's different modalities and formats products for APOA4 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the APOA4 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon.? The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles.? Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
| Target ID | GM-T68829 |
| Target Name | APOA4 |
| Gene ID | 337,11808,25080,702424,489392,101080570,537301,100062506 |
| Gene Symbol and Synonyms | Apo-AIV,Apoa-4,ApoA-IV,APOA4,apoAIV |
| Uniprot Accession | P06727,P02651,E2RE76,M3W955,Q32PJ2 |
| Uniprot Entry Name | APOA4_HUMAN,APOA4_RAT,APOA4_FELCA,APOA4_CANLF,APOA4_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Diabetic Nephropathy, Malignant neoplasm of bladder, Dent disease |
| Gene Ensembl | ENSG00000110244 |
| Target Classification | N/A |
Pre-made anti-APOA4 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-APOA4 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-APOA4 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-APOA4 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Recombinant multi-species APOA4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine APOA4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| APOA4 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made APOA4 viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| vGMLP000805 | human APOA4 Lentivirus particle | BC113596 | Human | Lentivirus particle | Detail |
| pGMLP000805 | human APOA4 Lentivirus plasmid | BC113596 | Human | Lentivirus plasmid | Detail |
| pGMLPm001801 | mouse Apoa4 Lentivirus plasmid | NM_007468.2 | Mouse | Lentivirus plasmid | Detail |
| pGMLPm005387 | mouse Apoa4 Lentivirus plasmid | NM_007468.2 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm001801 | mouse Apoa4 Lentivirus particle | NM_007468.2 | Mouse | Lentivirus particle | Detail |
| vGMLPm005387 | mouse Apoa4 Lentivirus particle | NM_007468.2 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.