EIF4E: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of EIF4E. The page also collects GeneMedi's different modalities and formats products for EIF4E in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the EIF4E target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
| Target ID | GM-T31186 |
| Target Name | EIF4E |
| Gene ID | 1977,13684,117045,706751,487870,101080377,281751,100066216 |
| Gene Symbol and Synonyms | AUTS19,CBP,EG668879,eIF-4E,EIF4E,Eif4e-ps,EIF4E1,EIF4EL1,EIF4F,If4e |
| Uniprot Accession | P06730,P63074,Q9N0T5 |
| Uniprot Entry Name | IF4E_HUMAN,IF4E_RAT,IF4E_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000151247 |
| Target Classification | Tumor-associated antigen (TAA) |
Pre-made anti-EIF4E inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-EIF4E monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-EIF4E mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-EIF4E monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species IF4E/ EIF4E/ AUTS19 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine EIF4E protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| EIF4E protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made EIF4E viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMLP004795 | human EIF4E Lentivirus plasmid | NM_001130678 | Human | Lentivirus plasmid | Detail |
| vGMLV000782 | human EIF4E Lentivirus particle | NM_001130679.2 | Human | Lentivirus particle | Detail |
| vGMLP004795 | human EIF4E Lentivirus particle | NM_001130678 | Human | Lentivirus particle | Detail |
| pGMLV000782 | human EIF4E Lentivirus plasmid | NM_001130679.2 | Human | Lentivirus plasmid | Detail |
| pGMLPm002420 | mouse Eif4e Lentivirus plasmid | NM_007917 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm002420 | mouse Eif4e Lentivirus particle | NM_007917 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.