HNF4A: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of HNF4A. The page also collects GeneMedi's different modalities and formats products for HNF4A in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the HNF4A target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
| Target ID | GM-T15514 |
| Target Name | HNF4A |
| Gene ID | 3172,15378,25735,717972,485884,101092841,509200,100056007 |
| Gene Symbol and Synonyms | FRTS4,HNF-4,HNF4,HNF4A,HNF4a7,HNF4a8,HNF4a9,HNF4alpha,MODY,MODY1,NR2A1,NR2A21,TCF,TCF-14,TCF14 |
| Uniprot Accession | P41235,P22449 |
| Uniprot Entry Name | HNF4A_HUMAN,HNF4A_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000101076 |
| Target Classification | Tumor-associated antigen (TAA) |
Pre-made anti-HNF4A inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-HNF4A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-HNF4A mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-HNF4A monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species HNF4A/ FRTS4/ HNF4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HNF4A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| HNF4A protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made HNF4A viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| vGMLV000653 | human HNF4A Lentivirus particle | NM_000457.4 | Human | Lentivirus particle | Detail |
| pGMLV000653 | human HNF4A Lentivirus plasmid | NM_000457.4 | Human | Lentivirus plasmid | Detail |
| pGMLV000669 | house mouse Hnf4a Lentivirus plasmid | NM_008261.3 | House Mouse | Lentivirus plasmid | Detail |
| pGMLPm002346 | mouse Hnf4a Lentivirus plasmid | NM_008261 | Mouse | Lentivirus plasmid | Detail |
| vGMLV000669 | house mouse Hnf4a Lentivirus particle | NM_008261.3 | House Mouse | Lentivirus particle | Detail |
| vGMLPm002346 | mouse Hnf4a Lentivirus particle | NM_008261 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.