TARDBP: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of TARDBP. The page also collects GeneMedi's different modalities and formats products for TARDBP in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TARDBP target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
| Target ID | GM-T08014 |
| Target Name | TARDBP |
| Gene ID | 23435,230908,298648,100423163,478234,101097257,540632,100051482 |
| Gene Symbol and Synonyms | 1190002A23Rik,ALS10,TARDBP,TDP-43,Tdp43 |
| Uniprot Accession | Q13148 |
| Uniprot Entry Name | TADBP_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000120948 |
| Target Classification | N/A |
Pre-made anti-TARDBP inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-TARDBP monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TARDBP mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-TARDBP monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species TADBP/ TARDBP/ ALS10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TARDBP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| TARDBP protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made TARDBP viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMLV000576 | human TARDBP Lentivirus plasmid | NM_007375.3 | Human | Lentivirus plasmid | Detail |
| vGMLP002200 | human TARDBP Lentivirus particle | NM_007375 | Human | Lentivirus particle | Detail |
| vGMLV000576 | human TARDBP Lentivirus particle | NM_007375.3 | Human | Lentivirus particle | Detail |
| vGMLV000575 | human TDP-43-mu Lentivirus particle | NM_007375.3 | Human | Lentivirus particle | Detail |
| pGMLV000575 | human TDP-43-mu Lentivirus plasmid | NM_007375.3 | Human | Lentivirus plasmid | Detail |
| pGMLP002200 | human TARDBP Lentivirus plasmid | NM_007375 | Human | Lentivirus plasmid | Detail |
| pGMLPm002631 | mouse Tardbp Lentivirus plasmid | NM_145556 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm002631 | mouse Tardbp Lentivirus particle | NM_145556 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.