TF: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of TF. The page also collects GeneMedi's different modalities and formats products for TF in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TF target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
| Target ID | GM-T02617 |
| Target Name | TF |
| Gene ID | 7018,22041,24825,477072,101085148,280705,100034176 |
| Gene Symbol and Synonyms | Cd176,HEL-S-71p,HP,hpx,LOC101085148,LOC477072,PRO1557,PRO2086,TF,Tfn,TFQTL1,Trf |
| Uniprot Accession | P02787,P12346,Q29443,P27425 |
| Uniprot Entry Name | TRFE_HUMAN,TRFE_RAT,TRFE_BOVIN,TRFE_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | IgA glomerulonephritis, Lung cancer, Malignant neoplasm of bladder, Type 2 diabetes mellitus, Type 2 diabetes mellitus with diabetic nephropathy, Diabetic Nephropathy, Congenital occlusion of ureteropelvic junction, Calculus of kidney |
| Gene Ensembl | ENSG00000091513 |
| Target Classification | N/A |
Pre-made anti-TF inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-TF benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TF mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-TF monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Multi-species TRFE/ TF/ HEL-S-71p VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TF VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| TF VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made TF viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMLP001587 | human TF Lentivirus plasmid | NM_001063 | Human | Lentivirus plasmid | Detail |
| vGMLP001587 | human TF Lentivirus particle | NM_001063 | Human | Lentivirus particle | Detail |
| pGMAAV000093 | mouse Trf AAV plasmid | NM_133977.2 | Mouse | AAV plasmid | Detail |
| pGMLPm005173 | mouse Trf Lentivirus plasmid | NM_133977.2 | Mouse | Lentivirus plasmid | Detail |
| vGMAAV000093 | mouse Trf AAV particle | NM_133977.2 | Mouse | AAV particle | Detail |
| vGMLPm005173 | mouse Trf Lentivirus particle | NM_133977.2 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.