ITGB1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of ITGB1. The page also collects GeneMedi's different modalities and formats products for ITGB1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the ITGB1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID | GM-T01851 |
| Target Name | ITGB1 |
| Gene ID | 3688,16412,24511,574312,477956,751821,281876,100055024 |
| Gene Symbol and Synonyms | 4633401G24Rik,CD29,FNRB,Gm9863,GPIIA,ITGB1,MDF2,MSK12,VLA-BETA,VLAB |
| Uniprot Accession | P05556,P49134,P53713,P53712 |
| Uniprot Entry Name | ITB1_HUMAN,ITB1_RAT,ITB1_FELCA,ITB1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Breast Cancer, Malignant neoplasm of prostate |
| Gene Ensembl | ENSG00000150093 |
| Target Classification | Checkpoint-Immuno Oncology |
Pre-made anti-ITGB1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-ITGB1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-ITGB1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-ITGB1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Multi-species ITB1/ ITGB1/ CD29 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ITGB1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| ITGB1 VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made ITGB1 viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMLV000660 | human ITGB1 Lentivirus plasmid | NM_002211.3 | Human | Lentivirus plasmid | Detail |
| vGMLP002682 | human ITGB1 Lentivirus particle | NM_002211 | Human | Lentivirus particle | Detail |
| pGMLP002682 | human ITGB1 Lentivirus plasmid | NM_002211 | Human | Lentivirus plasmid | Detail |
| vGMLV000660 | human ITGB1 Lentivirus particle | NM_002211.3 | Human | Lentivirus particle | Detail |
| pGMLV000147 | mouse Itgb1 Lentivirus plasmid | NM_010578.2 | Mouse | Lentivirus plasmid | Detail |
| vGMLV000147 | mouse Itgb1 Lentivirus particle | NM_010578.2 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.