HAVCR1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of HAVCR1. The page also collects GeneMedi's different modalities and formats products for HAVCR1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the HAVCR1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and other coronaviruses. [provided by RefSeq, Sep 2021]
| Target ID | GM-MP0572 |
| Target Name | HAVCR1 |
| Gene ID | 26762,715333,612069,101099778 |
| Gene Symbol and Synonyms | CD365,HAVCR,HAVCR-1,HAVCR1,KIM-1,KIM1,TIM,TIM-1,TIM1,TIMD-1,TIMD1 |
| Uniprot Accession | Q96D42 |
| Uniprot Entry Name | HAVR1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Renal fibrosis, Sickle Cell Nephropathy, Type 1 diabetes mellitus with diabetic nephropathy, Type 2 diabetes mellitus, Vasculitis, Vesicoureteral reflux, Acute kidney failure, Autosomal Dominant Polycystic Kidney Disease, Complications of kidney transplant, Congenital hydronephrosis, Cystic fibrosis with pulmonary manifestations, Injury to Kidney, Intraoperative Renal Injury, Kidney disease, Neonatal urinary tract infection, Nephropathy induced by heavy metals, Proteinuria, Renal cell carcinoma, Hydronephrosis, Coronary artery disease, Nephrotic syndrome with diffuse membranous glomerulonephritis |
| Gene Ensembl | ENSG00000113249 |
| Target Classification | N/A |
Pre-made anti-HAVCR1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-HAVCR1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-HAVCR1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-HAVCR1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody | Detail |
Multi-species HAVR1/ HAVCR1/ CD365 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HAVCR1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| HAVCR1 VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made HAVCR1 viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| vGMLP001952 | human HAVCR1 Lentivirus particle | NM_001308156.1? | Human | Lentivirus particle | Detail |
| pGMLP001952 | human HAVCR1 Lentivirus plasmid | NM_001308156.1? | Human | Lentivirus plasmid | Detail |
| pGMLPm003696 | mouse Havcr1 Lentivirus plasmid | NM_001166631.1 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm003696 | mouse Havcr1 Lentivirus particle | NM_001166631.1 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.