MFN2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of MFN2. The page also collects GeneMedi's different modalities and formats products for MFN2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the MFN2 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
| Target ID | GM-IP1173 |
| Target Name | MFN2 |
| Gene ID | 9927,170731,64476,100427191,487439,101101068,534574,100055966 |
| Gene Symbol and Synonyms | CMT2A,CMT2A2,CMT2A2A,CMT2A2B,CPRP1,D630023P19Rik,Fzo,HMSN6A,HSG,MARF,MFN2,MSL |
| Uniprot Accession | O95140,Q8R500 |
| Uniprot Entry Name | MFN2_HUMAN,MFN2_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000116688 |
| Target Classification | N/A |
Pre-made anti-MFN2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-MFN2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-MFN2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-MFN2 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Detail |
Recombinant multi-species MFN2/ CMT2A/ CMT2A2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MFN2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| MFN2 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made MFN2 viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMLV000716 | human MFN2 Lentivirus plasmid | NM_014874 | Human | Lentivirus plasmid | Detail |
| pGMLV000851 | human MFN2 Lentivirus plasmid | NM_014874.2 | Human | Lentivirus plasmid | Detail |
| vGMLV000851 | human MFN2 Lentivirus particle | NM_014874.2 | Human | Lentivirus particle | Detail |
| vGMLV000716 | human MFN2 Lentivirus particle | NM_014874 | Human | Lentivirus particle | Detail |
| pGMLV000871 | human MFN2 Lentivirus plasmid | NM_014874.1 | Human | Lentivirus plasmid | Detail |
| vGMLV000871 | human MFN2 Lentivirus particle | NM_014874.1 | Human | Lentivirus particle | Detail |
| pGMLV000580 | Norway rat Mfn2 Lentivirus plasmid | NM_130894.4 | Norway Rat | Lentivirus plasmid | Detail |
| pGMAD000368 | rat Mfn2 Adenovirus plasmid | NM_130894.4 | Rat | Adenovirus plasmid | Detail |
| pGMAD000479 | Norway rat Mfn2 Adenovirus plasmid | NM_130894.4 | Norway Rat | Adenovirus plasmid | Detail |
| vGMLV000580 | Norway rat Mfn2 Lentivirus particle | NM_130894.4 | Norway Rat | Lentivirus particle | Detail |
| vGMAD000368 | rat Mfn2 Adenovirus particle | NM_130894.4 | Rat | Adenovirus particle | Detail |
| vGMAD000479 | Norway rat Mfn2 Adenovirus particle | NM_130894.4 | Norway Rat | Adenovirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.