MFN2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of MFN2. The page also collects GeneMedi's different modalities and formats products for MFN2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the MFN2 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Introcelluar Protein.

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Target IDGM-IP1173
Target NameMFN2
Gene ID9927,170731,64476,100427191,487439,101101068,534574,100055966
Gene Symbol and SynonymsCMT2A,CMT2A2,CMT2A2A,CMT2A2B,CPRP1,D630023P19Rik,Fzo,HMSN6A,HSG,MARF,MFN2,MSL
Uniprot AccessionO95140,Q8R500
Uniprot Entry NameMFN2_HUMAN,MFN2_RAT
Protein Sub-locationIntrocelluar Protein
Category
DiseaseN/A
Gene EnsemblENSG00000116688
Target ClassificationN/A


Pre-made anti-MFN2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-MFN2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-MFN2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-MFN2 monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabDetail



Recombinant multi-species MFN2/ CMT2A/ CMT2A2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MFN2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
MFN2 proteinHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellDetail



Pre-made MFN2 viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
pGMLV000716human MFN2 Lentivirus plasmidNM_014874HumanLentivirus plasmidDetail
pGMLV000851human MFN2 Lentivirus plasmidNM_014874.2HumanLentivirus plasmidDetail
vGMLV000851human MFN2 Lentivirus particleNM_014874.2HumanLentivirus particleDetail
vGMLV000716human MFN2 Lentivirus particleNM_014874HumanLentivirus particleDetail
pGMLV000871human MFN2 Lentivirus plasmidNM_014874.1HumanLentivirus plasmidDetail
vGMLV000871human MFN2 Lentivirus particleNM_014874.1HumanLentivirus particleDetail
pGMLV000580Norway rat Mfn2 Lentivirus plasmidNM_130894.4Norway RatLentivirus plasmidDetail
pGMAD000368rat Mfn2 Adenovirus plasmidNM_130894.4RatAdenovirus plasmidDetail
pGMAD000479Norway rat Mfn2 Adenovirus plasmidNM_130894.4Norway RatAdenovirus plasmidDetail
vGMLV000580Norway rat Mfn2 Lentivirus particleNM_130894.4Norway RatLentivirus particleDetail
vGMAD000368rat Mfn2 Adenovirus particleNM_130894.4RatAdenovirus particleDetail
vGMAD000479Norway rat Mfn2 Adenovirus particleNM_130894.4Norway RatAdenovirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.