DLL3: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of DLL3. The page also collects GeneMedi's different modalities and formats products for DLL3 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the DLL3 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
| Target ID | GM-IP0082 |
| Target Name | DLL3 |
| Gene ID | 10683,13389,114125,697453,484508,101095456,505993,100067648 |
| Gene Symbol and Synonyms | DLL3,pu,pudgy,SCDO1 |
| Uniprot Accession | Q9NYJ7,O88671 |
| Uniprot Entry Name | DLL3_HUMAN,DLL3_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000090932 |
| Target Classification | Checkpoint-Immuno Oncology |
Pre-made DLL3-specific INN-index biosimilar (antibody&conjugates)
Anti-DLL3 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
| Cat No. | Products Name (INN Index) | INN Name | Previous Name | Target | Format | Detail |
| GMP-Bios-ab-497 | Pre-Made Rovalpituzumab biosimilar, Whole mAb ADC, Anti-DLL3 Antibody: Anti-SCDO1 therapeutic antibody | Rovalpituzumab | DLL3 | Whole mAb ADC | Detail | |
| GMP-Bios-INN-980 | Pre-Made Rovalpituzumab Tesirine Biosimilar, Whole Mab Adc, Anti-Dll3 Antibody: Anti-SCDO1 therapeutic antibody Drug Conjugate | rovalpituzumab tesirine | DLL3 | Whole mAb ADC | Detail | |
| GMP-Bios-ab-552 | Pre-Made Tarlatamab biosimilar, Bispecific scFv, Anti-DLL3;CD3E Antibody: Anti-SCDO1;T3E/TCRE/IMD18 therapeutic antibody | Tarlatamab | DLL3;CD3E | Bispecific scFv | Detail |
Click to check more INN-indexed antibody & protein biosimilar
Pre-made anti-DLL3 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-DLL3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-DLL3 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-DLL3 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species DLL3/ SCDO1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DLL3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| DLL3 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made DLL3 viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMLV000662 | human DLL3 Lentivirus plasmid | NM_016941.3 | Human | Lentivirus plasmid | Detail |
| vGMLV000662 | human DLL3 Lentivirus particle | NM_016941.3 | Human | Lentivirus particle | Detail |
| pGMLPm005066 | mouse Dll3 Lentivirus plasmid | NM_007866.2 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm005066 | mouse Dll3 Lentivirus particle | NM_007866.2 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.