Human APOE/AD2/APO-E ORF/cDNA clone-Adeno-associate virus(AAV) particle (NM_000041.4)

Cat. No.: vGMAAV001436

Pre-made Human APOE/AD2/APO-E Adeno-associated virus particle for APOE in-vivo study, mechanism of action (MOA) research and APOE-associated gene therapy development.

At GM Vector Core (GMVC), we stand at the forefront of custom AAV development and produce distinct grades of AAVs employing state-of-the-art methodologies. Uncover more about our expertise.

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name AAV serotype AAV Grade AAV quantity
vGMAAV001436 Human APOE Adeno-associate virus(AAV) particle AAV1, AAV2, AAV2 variant (Y444F), AAV2 variant (Y272F, Y444F, Y500F, Y730F), AAV2 variant (Y444F, Y730F, Y500F, Y272F, Y704F, Y252F), AAV2 variant(AAV2.7m8), AAV5, AAV6, AAV8, AAV8-1m, AAV8-2m, AAV8 variant (Y733F, Y447F, Y275), AAV9, AAV-Rh.10, AAV-DJ, AAV-DJ/8, AAV-Retro (Retrograde), AAV9-PHP.B, AAV9-PHP.eB, AAV9-PHP.S, AAV-BR1, AAV-2i8, AAV-SIG, AAV-VEC, AAV4, AAV6.2, AAV6.2FF Pilot Grade 1.0E+12VG/ml
5.0E+12VG/ml
1E+13VG/ml
5E+13VG/ml
1E+14VG/ml
Research Grade 1.0E+12VG/ml
5.0E+12VG/ml
1E+13VG/ml
5E+13VG/ml
1E+14VG/ml
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMAAV001436
Gene Name APOE
Accession Number NM_000041.4
Gene ID 348
Species Human
Product Type Adeno-associate virus(AAV) particle (overexpression)
Insert Length 954 bp
Gene Alias AD2,APO-E,ApoE4,LDLCQ5,LPG
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter TBG
Resistance Amplicin
ORF Nucleotide Sequence ATGAAGGTTCTGTGGGCTGCGTTGCTGGTCACATTCCTGGCAGGATGCCAGGCCAAGGTGGAGCAAGCGGTGGAGACAGAGCCGGAGCCCGAGCTGCGCCAGCAGACCGAGTGGCAGAGCGGCCAGCGCTGGGAACTGGCACTGGGTCGCTTTTGGGATTACCTGCGCTGGGTGCAGACACTGTCTGAGCAGGTGCAGGAGGAGCTGCTCAGCTCCCAGGTCACCCAGGAACTGAGGGCGCTGATGGACGAGACCATGAAGGAGTTGAAGGCCTACAAATCGGAACTGGAGGAACAACTGACCCCGGTGGCGGAGGAGACGCGGGCACGGCTGTCCAAGGAGCTGCAGGCGGCGCAGGCCCGGCTGGGCGCGGACATGGAGGACGTGTGCGGCCGCCTGGTGCAGTACCGCGGCGAGGTGCAGGCCATGCTCGGCCAGAGCACCGAGGAGCTGCGGGTGCGCCTCGCCTCCCACCTGCGCAAGCTGCGTAAGCGGCTCCTCCGCGATGCCGATGACCTGCAGAAGCGCCTGGCAGTGTACCAGGCCGGGGCCCGCGAGGGCGCCGAGCGCGGCCTCAGCGCCATCCGCGAGCGCCTGGGGCCCCTGGTGGAACAGGGCCGCGTGCGGGCCGCCACTGTGGGCTCCCTGGCCGGCCAGCCGCTACAGGAGCGGGCCCAGGCCTGGGGCGAGCGGCTGCGCGCGCGGATGGAGGAGATGGGCAGCCGGACCCGCGACCGCCTGGACGAGGTGAAGGAGCAGGTGGCGGAGGTGCGCGCCAAGCTGGAGGAGCAGGCCCAGCAGATACGCCTGCAGGCCGAGGCCTTCCAGGCCCGCCTCAAGAGCTGGTTCGAGCCCCTGGTGGAAGACATGCAGCGCCAGTGGGCCGGGCTGGTGGAGAAGGTGCAGGCTGCCGTGGGCACCAGCGCCGCCCCTGTGCCCAGCGACAATCACTGA
ORF Protein Sequence MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T21689-Ab Anti-APOE/ AD2/ APO-E monoclonal antibody
    Target Antigen GM-Tg-g-T21689-Ag APOE VLP (virus-like particle)
    ORF Viral Vector pGMLP001912 Human APOE Lentivirus plasmid
    ORF Viral Vector pGMLV001748 Human APOE Lentivirus plasmid
    ORF Viral Vector pGMAAV000334 Human APOE Adeno-associate virus(AAV) plasmid
    ORF Viral Vector pGMAAV001436 Human APOE Adeno-associate virus(AAV) plasmid
    ORF Viral Vector pGMPC004755 Human APOE Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP001912 Human APOE Lentivirus particle
    ORF Viral Vector vGMLV001748 Human APOE Lentivirus particle
    ORF Viral Vector vGMAAV000334 Human APOE Adeno-associate virus(AAV) particle
    ORF Viral Vector vGMAAV001436 Human APOE Adeno-associate virus(AAV) particle


    Target information

    Target ID GM-T21689
    Target Name APOE
    Gene Group Identifier
    （Target Gene ID in Homo species)         		348
    Gene ID 100065481 (Equus caballus), 101086769 (Felis catus), 11816 (Mus musculus), 25728 (Rattus norvegicus)
    281004 (Bos taurus), 348 (Homo sapiens), 476438 (Canis lupus familiaris), 714623 (Macaca mulatta)
    Gene Symbols & Synonyms APOE,Apoe,Apo-E,APOEA,AD2,LPG,APO-E,ApoE4,LDLCQ5
    Target Alternative Names AD2,APO-E,APOE,APOEA,Apo-E,ApoE4,Apoe,Apolipoprotein E,LDLCQ5,LPG
    Uniprot Accession P02649,P02650,P08226,P18649,Q03247,Q28502
    Additional SwissProt Accessions: P08226,P02650,Q03247,P02649,P18649,Q28502
    Uniprot Entry Name
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Diagnostics Biomarker
    Disease cancer, Type 1 diabetes mellitus, Alzheimer's Disease, Breast neoplasms, Dent disease, Malignant neoplasm of bladder, Other diseases of intestines (K55-K64)
    Disease from KEGG Cholesterol metabolism, Alzheimer disease
    Gene Ensembl ENSECAG00000008236, ENSMUSG00000002985, ENSBTAG00000010123, ENSG00000130203, ENSCAFG00845006705, ENSMMUG00000014305
    Target Classification


    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.