Human TGFBR1/AAT5/ACVRLK4 ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_004612)

Cat. No.: pGMPC000232
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human TGFBR1/AAT5/ACVRLK4 Non-Viral expression plasmid (overexpression vector) for mouse TGFBR1 overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC000232
Gene Name TGFBR1
Accession Number NM_004612
Gene ID 7046
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 1512 bp
Gene Alias AAT5,ACVRLK4,ALK-5,ALK5,ESS1,LDS1,LDS1A,LDS2A,MSSE,SKR4,tbetaR-I,TBR-i,TBRI,TGFR-1
Fluorescent Reporter EGFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin
ORF Nucleotide Sequence ATGGAGGCGGCGGTCGCTGCTCCGCGTCCCCGGCTGCTCCTCCTCGTGCTGGCGGCGGCGGCGGCGGCGGCGGCGGCGCTGCTCCCGGGGGCGACGGCGTTACAGTGTTTCTGCCACCTCTGTACAAAAGACAATTTTACTTGTGTGACAGATGGGCTCTGCTTTGTCTCTGTCACAGAGACCACAGACAAAGTTATACACAACAGCATGTGTATAGCTGAAATTGACTTAATTCCTCGAGATAGGCCGTTTGTATGTGCACCCTCTTCAAAAACTGGGTCTGTGACTACAACATATTGCTGCAATCAGGACCATTGCAATAAAATAGAACTTCCAACTACTGTAAAGTCATCACCTGGCCTTGGTCCTGTGGAACTGGCAGCTGTCATTGCTGGACCAGTGTGCTTCGTCTGCATCTCACTCATGTTGATGGTCTATATCTGCCACAACCGCACTGTCATTCACCATCGAGTGCCAAATGAAGAGGACCCTTCATTAGATCGCCCTTTTATTTCAGAGGGTACTACGTTGAAAGACTTAATTTATGATATGACAACGTCAGGTTCTGGCTCAGGTTTACCATTGCTTGTTCAGAGAACAATTGCGAGAACTATTGTGTTACAAGAAAGCATTGGCAAAGGTCGATTTGGAGAAGTTTGGAGAGGAAAGTGGCGGGGAGAAGAAGTTGCTGTTAAGATATTCTCCTCTAGAGAAGAACGTTCGTGGTTCCGTGAGGCAGAGATTTATCAAACTGTAATGTTACGTCATGAAAACATCCTGGGATTTATAGCAGCAGACAATAAAGACAATGGTACTTGGACTCAGCTCTGGTTGGTGTCAGATTATCATGAGCATGGATCCCTTTTTGATTACTTAAACAGATACACAGTTACTGTGGAAGGAATGATAAAACTTGCTCTGTCCACGGCGAGCGGTCTTGCCCATCTTCACATGGAGATTGTTGGTACCCAAGGAAAGCCAGCCATTGCTCATAGAGATTTGAAATCAAAGAATATCTTGGTAAAGAAGAATGGAACTTGCTGTATTGCAGACTTAGGACTGGCAGTAAGACATGATTCAGCCACAGATACCATTGATATTGCTCCAAACCACAGAGTGGGAACAAAAAGGTACATGGCCCCTGAAGTTCTCGATGATTCCATAAATATGAAACATTTTGAATCCTTCAAACGTGCTGACATCTATGCAATGGGCTTAGTATTCTGGGAAATTGCTCGACGATGTTCCATTGGTGGAATTCATGAAGATTACCAACTGCCTTATTATGATCTTGTACCTTCTGACCCATCAGTTGAAGAAATGAGAAAAGTTGTTTGTGAACAGAAGTTAAGGCCAAATATCCCAAACAGATGGCAGAGCTGTGAAGCCTTGAGAGTAATGGCTAAAATTATGAGAGAATGTTGGTATGCCAATGGAGCAGCTAGGCTTACAGCATTGCGGATTAAGAAAACATTATCGCAACTCAGTCAACAGGAAGGCATCAAAATGTAA
ORF Protein Sequence MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T53389-Ab Anti-TGFR1/ TGFBR1/ AAT5 monoclonal antibody
    Target Antigen GM-Tg-g-T53389-Ag TGFBR1 VLP (virus-like particle)
    Cytokine cks-Tg-g-GM-T53389 transforming growth factor, beta receptor 1 (TGFBR1) protein & antibody
    ORF Viral Vector pGMLP001434 Human TGFBR1 Lentivirus plasmid
    ORF Viral Vector pGMLP005234 Human TGFBR1 Lentivirus plasmid
    ORF Viral Vector pGMLP005816 Human TGFBR1 Lentivirus plasmid
    ORF Viral Vector pGMLV001800 Human TGFBR1 Lentivirus plasmid
    ORF Viral Vector pGMLP-SPh-040 Human TGFBR1 Lentivirus plasmid
    ORF Viral Vector pGMAP-SPh-180 Human TGFBR1 Adenovirus plasmid
    ORF Viral Vector pGMPC000232 Human TGFBR1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001077 Human TGFBR1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP001434 Human TGFBR1 Lentivirus particle
    ORF Viral Vector vGMLP005234 Human TGFBR1 Lentivirus particle
    ORF Viral Vector vGMLP005816 Human TGFBR1 Lentivirus particle
    ORF Viral Vector vGMLV001800 Human TGFBR1 Lentivirus particle
    ORF Viral Vector vGMLP-SPh-040 Human TGFBR1 Lentivirus particle
    ORF Viral Vector vGMAP-SPh-180 Human TGFBR1 Adenovirus particle


    Target information

    Target ID GM-T53389
    Target Name TGFBR1
    Gene Group Identifier
    （Target Gene ID in Homo species)         		7046
    Gene ID 100034117 (Equus caballus), 101094057 (Felis catus), 21812 (Mus musculus), 282382 (Bos taurus)
    29591 (Rattus norvegicus), 481628 (Canis lupus familiaris), 7046 (Homo sapiens), 714952 (Macaca mulatta)
    Gene Symbols & Synonyms TGFBR1,Tgfbr1,ALK5,ESK2,Alk-5,TGFR-1,TbetaRI,TbetaR-I,Alk5,Skr4,Tgfr-1,tbetaR-I,AAT5,ESS1,LDS1,MSSE,SKR4,TBRI,ALK-5,LDS1A,LDS2A,TBR-i,ACVRLK4
    Target Alternative Names AAT5,ACVRLK4,ALK-5,ALK5,ALK5),Activin A receptor type II-like protein kinase of 53kD,Activin receptor-like kinase 5 (ALK-5,Alk-5,Alk5,ESK2,ESS1,LDS1,LDS1A,LDS2A,MSSE,SKR4,Serine/threonine-protein kinase receptor R4 (SKR4),Skr4,TBR-i,TBRI,TGF-beta receptor type-1,TGF-beta type I receptor,TGFBR1,TGFR-1,TbetaR-I,TbetaR-I),TbetaRI,Tgfbr1,Tgfr-1,Transforming growth factor-beta receptor type I (TGF-beta receptor type I,tbetaR-I
    Uniprot Accession O46680,P36897,P80204,Q64729
    Additional SwissProt Accessions: Q64729,O46680,P80204,P36897
    Uniprot Entry Name
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Immuno-oncology Target, Cytokine Target
    Disease cancer
    Disease from KEGG MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, Cellular senescence, TGF-beta signaling pathway, Osteoclast differentiation, Hippo signaling pathway, Adherens junction, Th17 cell differentiation, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Chagas disease, Hepatitis B, Human T-cell leukemia virus 1 infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Chronic myeloid leukemia, Hepatocellular carcinoma, Gastric cancer
    Gene Ensembl ENSECAG00000004757, ENSMUSG00000007613, ENSBTAG00000018035, ENSCAFG00845007708, ENSG00000106799, ENSMMUG00000001304
    Target Classification Cytokine Receptor, Kinase, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)


    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.