Human SIRT1/SIR2/SIR2alpha ORF/cDNA clone-Adenovirus plasmid (NM_012238)

Cat. No.: pGMAP000577
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human SIRT1/SIR2/SIR2alpha adenoviral expression plasmid for SIRT1 adenovirus packaging, SIRT1 adenovirus.

Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.

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Product Description

Catalog ID pGMAP000577
Gene Name SIRT1
Accession Number NM_012238
Gene ID 23411
Species Human
Product Type Adenovirus plasmid (overexpression)
Insert Length 2244 bp
Gene Alias SIR2,SIR2alpha,SIR2L1
Fluorescent Reporter GFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin
ORF Nucleotide Sequence ATGGCGGACGAGGCGGCCCTCGCCCTTCAGCCCGGCGGCTCCCCCTCGGCGGCGGGGGCCGACAGGGAGGCCGCGTCGTCCCCCGCCGGGGAGCCGCTCCGCAAGAGGCCGCGGAGAGATGGTCCCGGCCTCGAGCGGAGCCCGGGCGAGCCCGGTGGGGCGGCCCCAGAGCGTGAGGTGCCGGCGGCGGCCAGGGGCTGCCCGGGTGCGGCGGCGGCGGCGCTGTGGCGGGAGGCGGAGGCAGAGGCGGCGGCGGCAGGCGGGGAGCAAGAGGCCCAGGCGACTGCGGCGGCTGGGGAAGGAGACAATGGGCCGGGCCTGCAGGGCCCATCTCGGGAGCCACCGCTGGCCGACAACTTGTACGACGAAGACGACGACGACGAGGGCGAGGAGGAGGAAGAGGCGGCGGCGGCGGCGATTGGGTACCGAGATAACCTTCTGTTCGGTGATGAAATTATCACTAATGGTTTTCATTCCTGTGAAAGTGATGAGGAGGATAGAGCCTCACATGCAAGCTCTAGTGACTGGACTCCAAGGCCACGGATAGGTCCATATACTTTTGTTCAGCAACATCTTATGATTGGCACAGATCCTCGAACAATTCTTAAAGATTTATTGCCGGAAACAATACCTCCACCTGAGTTGGATGATATGACACTGTGGCAGATTGTTATTAATATCCTTTCAGAACCACCAAAAAGGAAAAAAAGAAAAGATATTAATACAATTGAAGATGCTGTGAAATTACTGCAAGAGTGCAAAAAAATTATAGTTCTAACTGGAGCTGGGGTGTCTGTTTCATGTGGAATACCTGACTTCAGGTCAAGGGATGGTATTTATGCTCGCCTTGCTGTAGACTTCCCAGATCTTCCAGATCCTCAAGCGATGTTTGATATTGAATATTTCAGAAAAGATCCAAGACCATTCTTCAAGTTTGCAAAGGAAATATATCCTGGACAATTCCAGCCATCTCTCTGTCACAAATTCATAGCCTTGTCAGATAAGGAAGGAAAACTACTTCGCAACTATACCCAGAACATAGACACGCTGGAACAGGTTGCGGGAATCCAAAGGATAATTCAGTGTCATGGTTCCTTTGCAACAGCATCTTGCCTGATTTGTAAATACAAAGTTGACTGTGAAGCTGTACGAGGAGATATTTTTAATCAGGTAGTTCCTCGATGTCCTAGGTGCCCAGCTGATGAACCGCTTGCTATCATGAAACCAGAGATTGTGTTTTTTGGTGAAAATTTACCAGAACAGTTTCATAGAGCCATGAAGTATGACAAAGATGAAGTTGACCTCCTCATTGTTATTGGGTCTTCCCTCAAAGTAAGACCAGTAGCACTAATTCCAAGTTCCATACCCCATGAAGTGCCTCAGATATTAATTAATAGAGAACCTTTGCCTCATCTGCATTTTGATGTAGAGCTTCTTGGAGACTGTGATGTCATAATTAATGAATTGTGTCATAGGTTAGGTGGTGAATATGCCAAACTTTGCTGTAACCCTGTAAAGCTTTCAGAAATTACTGAAAAACCTCCACGAACACAAAAAGAATTGGCTTATTTGTCAGAGTTGCCACCCACACCTCTTCATGTTTCAGAAGACTCAAGTTCACCAGAAAGAACTTCACCACCAGATTCTTCAGTGATTGTCACACTTTTAGACCAAGCAGCTAAGAGTAATGATGATTTAGATGTGTCTGAATCAAAAGGTTGTATGGAAGAAAAACCACAGGAAGTACAAACTTCTAGGAATGTTGAAAGTATTGCTGAACAGATGGAAAATCCGGATTTGAAGAATGTTGGTTCTAGTACTGGGGAGAAAAATGAAAGAACTTCAGTGGCTGGAACAGTGAGAAAATGCTGGCCTAATAGAGTGGCAAAGGAGCAGATTAGTAGGCGGCTTGATGGTAATCAGTATCTGTTTTTGCCACCAAATCGTTACATTTTCCATGGCGCTGAGGTATATTCAGACTCTGAAGATGACGTCTTATCCTCTAGTTCTTGTGGCAGTAACAGTGATAGTGGGACATGCCAGAGTCCAAGTTTAGAAGAACCCATGGAGGATGAAAGTGAAATTGAAGAATTCTACAATGGCTTAGAAGATGAGCCTGATGTTCCAGAGAGAGCTGGAGGAGCTGGATTTGGGACTGATGGAGATGATCAAGAGGCAATTAATGAAGCTATATCTGTGAAACAGGAAGTAACAGACATGAACTATCCATCAAACAAATCATAG
ORF Protein Sequence MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T14731-Ab Anti-SIRT1 monoclonal antibody
    Target Antigen GM-Tg-g-T14731-Ag SIRT1 protein
    ORF Viral Vector pGMLV000135 Human SIRT1 Lentivirus plasmid
    ORF Viral Vector pGMLV000525 Human SIRT1 Lentivirus plasmid
    ORF Viral Vector pGMLV000931 Human SIRT1 Lentivirus plasmid
    ORF Viral Vector pGMAD000463 Human SIRT1 Adenovirus plasmid
    ORF Viral Vector pGMAD000579 Human SIRT1 Adenovirus plasmid
    ORF Viral Vector pGMAP000577 Human SIRT1 Adenovirus plasmid
    ORF Viral Vector pGMLP-SPh-135 Human SIRT1 Lentivirus plasmid
    ORF Viral Vector pGMAP-SPh-275 Human SIRT1 Adenovirus plasmid
    ORF Viral Vector pGMPC000017 Human SIRT1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001352 Human SIRT1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV000135 Human SIRT1 Lentivirus particle
    ORF Viral Vector vGMLV000525 Human SIRT1 Lentivirus particle
    ORF Viral Vector vGMLV000931 Human SIRT1 Lentivirus particle
    ORF Viral Vector vGMAD000463 Human SIRT1 Adenovirus particle
    ORF Viral Vector vGMAD000579 Human SIRT1 Adenovirus particle
    ORF Viral Vector vGMAP000577 Human SIRT1 Adenovirus particle
    ORF Viral Vector vGMLP-SPh-135 Human SIRT1 Lentivirus particle
    ORF Viral Vector vGMAP-SPh-275 Human SIRT1 Adenovirus particle


    Target information

    Target ID GM-T14731
    Target Name SIRT1
    Gene Group Identifier
    （Target Gene ID in Homo species)         		23411
    Gene ID 100072571 (Equus caballus), 101087610 (Felis catus), 23411 (Homo sapiens), 309757 (Rattus norvegicus)
    489012 (Canis lupus familiaris), 613629 (Bos taurus), 695682 (Macaca mulatta), 93759 (Mus musculus)
    Gene Symbols & Synonyms SIRT1,Sirt1,SIR2,SIR2L1,SIR2alpha,Sir2,sirtuin-1,Sir2a,Sir2alpha
    Target Alternative Names NAD-dependent protein deacetylase sirtuin-1,NAD-dependent protein deacylase sirtuin-1,Regulatory protein SIR2 homolog 1,SIR2,SIR2-like protein 1 (hSIR2),SIR2L1,SIR2alpha,SIRT1,Sir2,Sir2a,Sir2alpha,Sirt1,hSIRT1,sirtuin-1
    Uniprot Accession A0A0G2JZ79,Q923E4,Q96EB6
    Additional SwissProt Accessions: Q96EB6,A0A0G2JZ79,Q923E4
    Uniprot Entry Name
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease cancer
    Disease from KEGG Metabolic pathways, FoxO signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Alcoholic liver disease, Amphetamine addiction
    Gene Ensembl ENSECAG00000013909, ENSG00000096717, ENSCAFG00845001191, ENSBTAG00000014023, ENSMMUG00000030531, ENSMUSG00000020063
    Target Classification Epigenetic, Tumor-associated antigen (TAA)


    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.