Human MAPT/DDPAC/FTDP-17 ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_005910.5)

Cat. No.: pGMAAV000031
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human MAPT/DDPAC/FTDP-17 Adeno-associated virus expression plasmid (ITR-vector) for MAPT AAV packaging, MAPT AAV production.The purified Human MAPT/DDPAC/FTDP-17 AAV particle serves as an invaluable asset for in-depth in vivo MAPT studies, mechanism of action (MOA) research, and the evolution of MAPT-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

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Product Description

Catalog ID pGMAAV000031
Gene Name MAPT
Accession Number NM_005910.5
Gene ID 4137
Species Human
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 1326 bp
Gene Alias DDPAC,FTDP-17,MAPTL,MSTD,MTBT1,MTBT2,PPND,PPP1R103,TAU
Fluorescent Reporter GFP
Mammalian Cell Selection Null
Fusion Tag Null
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGCTGAGCCCCGCCAGGAGTTCGAAGTGATGGAAGATCACGCTGGGACGTACGGGTTGGGGGACAGGAAAGATCAGGGGGGCTACACCATGCACCAAGACCAAGAGGGTGACACGGACGCTGGCCTGAAAGAATCTCCCCTGCAGACCCCCACTGAGGACGGATCTGAGGAACCGGGCTCTGAAACCTCTGATGCTAAGAGCACTCCAACAGCGGAAGATGTGACAGCACCCTTAGTGGATGAGGGAGCTCCCGGCAAGCAGGCTGCCGCGCAGCCCCACACGGAGATCCCAGAAGGAACCACAGCTGAAGAAGCAGGCATTGGAGACACCCCCAGCCTGGAAGACGAAGCTGCTGGTCACGTGACCCAAGCTCGCATGGTCAGTAAAAGCAAAGACGGGACTGGAAGCGATGACAAAAAAGCCAAGGGGGCTGATGGTAAAACGAAGATCGCCACACCGCGGGGAGCAGCCCCTCCAGGCCAGAAGGGCCAGGCCAACGCCACCAGGATTCCAGCAAAAACCCCGCCCGCTCCAAAGACACCACCCAGCTCTGGTGAACCTCCAAAATCAGGGGATCGCAGCGGCTACAGCAGCCCCGGCTCCCCAGGCACTCCCGGCAGCCGCTCCCGCACCCCGTCCCTTCCAACCCCACCCACCCGGGAGCCCAAGAAGGTGGCAGTGGTCCGTACTCCACCCAAGTCGCCGTCTTCCGCCAAGAGCCGCCTGCAGACAGCCCCCGTGCCCATGCCAGACCTGAAGAATGTCAAGTCCAAGATCGGCTCCACTGAGAACCTGAAGCACCAGCCGGGAGGCGGGAAGGTGCAGATAATTAATAAGAAGCTGGATCTTAGCAACGTCCAGTCCAAGTGTGGCTCAAAGGATAATATCAAACACGTCCCGGGAGGCGGCAGTGTGCAAATAGTCTACAAACCAGTTGACCTGAGCAAGGTGACCTCCAAGTGTGGCTCATTAGGCAACATCCATCATAAACCAGGAGGTGGCCAGGTGGAAGTAAAATCTGAGAAGCTTGACTTCAAGGACAGAGTCCAGTCGAAGATTGGGTCCCTGGACAATATCACCCACGTCCCTGGCGGAGGAAATAAAAAGATTGAAACCCACAAGCTGACCTTCCGCGAGAACGCCAAAGCCAAGACAGACCACGGGGCGGAGATCGTGTACAAGTCGCCAGTGGTGTCTGGGGACACGTCTCCACGGCATCTCAGCAATGTCTCCTCCACCGGCAGCATCGACATGGTAGACTCGCCCCAGCTCGCCACGCTAGCTGACGAGGTGTCTGCCTCCCTGGCCAAGCAGGGTTTGTGA
ORF Protein Sequence MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Biosimilar GMP-Bios-ab-572 Pre-Made Tilavonemab biosimilar, Whole mAb, Anti-MAPT Antibody: Anti-DDPAC/FTDP-17/MSTD/MTBT1/MTBT2/PPND/PPP1R103/TAU/tau-40 therapeutic antibody
    Biosimilar GMP-Bios-ab-635 Pre-Made Zagotenemab biosimilar, Whole mAb, Anti-MAPT Antibody: Anti-DDPAC/FTDP-17/MSTD/MTBT1/MTBT2/PPND/PPP1R103/TAU/tau-40 therapeutic antibody
    Biosimilar GMP-Bios-ab-512 Pre-Made Semorinemab biosimilar, Whole mAb, Anti-MAPT Antibody: Anti-DDPAC/FTDP-17/MSTD/MTBT1/MTBT2/PPND/PPP1R103/TAU/tau-40 therapeutic antibody
    Biosimilar GMP-Bios-ab-061 Pre-Made Bepranemab biosimilar, Whole mAb, Anti-MAPT Antibody: Anti-DDPAC/FTDP-17/MSTD/MTBT1/MTBT2/PPND/PPP1R103/TAU/tau-40 therapeutic antibody
    Biosimilar GMP-Bios-ab-252 Pre-Made Gosuranemab biosimilar, Whole mAb, Anti-MAPT Antibody: Anti-DDPAC/FTDP-17/MSTD/MTBT1/MTBT2/PPND/PPP1R103/TAU/tau-40 therapeutic antibody
    Target Antibody GM-Tg-g-T45593-Ab Anti-TAU/ MAPT/ DDPAC monoclonal antibody
    Target Antigen GM-Tg-g-T45593-Ag MAPT VLP (virus-like particle)
    ORF Viral Vector pGMLV000202 Human MAPT Lentivirus plasmid
    ORF Viral Vector pGMAAV000031 Human MAPT Adeno-associate virus(AAV) plasmid
    ORF Viral Vector pGMPC001846 Human MAPT Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV000202 Human MAPT Lentivirus particle
    ORF Viral Vector vGMAAV000031 Human MAPT Adeno-associate virus(AAV) particle


    Target information

    Target ID GM-T45593
    Target Name TAU/MAPT
    Gene Group Identifier
    （Target Gene ID in Homo species)         		4137
    Gene ID 100054638 (Equus caballus), 101089557 (Felis catus), 17762 (Mus musculus), 281296 (Bos taurus)
    29477 (Rattus norvegicus), 4137 (Homo sapiens), 480488 (Canis lupus familiaris), 574327 (Macaca mulatta)
    Gene Symbols & Synonyms MAPT,Mapt,Tau,Mtapt,PHF-tau,tau,pTau,RNPTAU,MAPT_0N4R,MAPT_1N4R,MAPT_2N4R,TAU,FTD1,MSTD,PPND,DDPAC,MAPTL,MTBT1,MTBT2,tau-40,FTDP-17,PPP1R103,Tau-PHF6
    Target Alternative Names TAU, MAPT,Microtubule-associated protein tau,Neurofibrillary tangle protein, Paired helical filament-tau (PHF-tau),TAU,FTD1,MSTD,PPND,DDPAC,MAPTL,MTBT1,MTBT2,tau-40,FTDP-17,PPP1R103,Tau-PHF6
    Uniprot Accession P10636,P10637,P19332,P29172,P57786
    Additional SwissProt Accessions: P10637,P29172,P19332,P10636,P57786
    Uniprot Entry Name
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Diagnostics Biomarker, INN Index
    Disease Breast Cancer
    Disease from KEGG MAPK signaling pathway, Alzheimer disease
    Gene Ensembl ENSECAG00000001205, ENSMUSG00000018411, ENSBTAG00000017512, ENSG00000186868, ENSCAFG00845022253, ENSMMUG00000004122
    Target Classification


    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.