Recombinant multi-species Alpha Tubulin/TUBA1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Alpha Tubulin/TUBA1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
The Alternative Names of target: Alpha Tubulin,Alpha-tubulin 3,B-ALPHA-1,LIS3,TUBA1A,TUBA3,Tuba-1,Tuba1,Tuba1a,Tubulin B-alpha-1,Tubulin alpha-1A chain,Tubulin alpha-3 chain

Target products collectionGo to Alpha Tubulin/TUBA1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-TA062-Ag-1/ GM-Tg-hg-TA062-Ag-2 Human Alpha Tubulin/TUBA1A protein Human
GM-Tg-rg-TA062-Ag-1/ GM-Tg-rg-TA062-Ag-2 Rat Alpha Tubulin/TUBA1A protein Rat
GM-Tg-mg-TA062-Ag-1/ GM-Tg-mg-TA062-Ag-2 Mouse Alpha Tubulin/TUBA1A protein Mouse
GM-Tg-cynog-TA062-Ag-1/ GM-Tg-cynog-TA062-Ag-2 Cynomolgus/Rhesus macaque Alpha Tubulin/TUBA1A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-TA062-Ag-1/ GM-Tg-felg-TA062-Ag-2 Feline Alpha Tubulin/TUBA1A protein Feline
GM-Tg-cang-TA062-Ag-1/ GM-Tg-cang-TA062-Ag-2 Canine Alpha Tubulin/TUBA1A protein Canine
GM-Tg-bovg-TA062-Ag-1/ GM-Tg-bovg-TA062-Ag-2 Bovine Alpha Tubulin/TUBA1A protein Bovine
GM-Tg-equg-TA062-Ag-1/ GM-Tg-equg-TA062-Ag-2 Equine Alpha Tubulin/TUBA1A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-TA062-Ag-1/ GM-Tg-hg-TA062-Ag-2; GM-Tg-rg-TA062-Ag-1/ GM-Tg-rg-TA062-Ag-2;
GM-Tg-mg-TA062-Ag-1/ GM-Tg-mg-TA062-Ag-2; GM-Tg-cynog-TA062-Ag-1/ GM-Tg-cynog-TA062-Ag-2;
GM-Tg-felg-TA062-Ag-1/ GM-Tg-felg-TA062-Ag-2; GM-Tg-cang-TA062-Ag-1/ GM-Tg-cang-TA062-Ag-2;
GM-Tg-bovg-TA062-Ag-1/ GM-Tg-bovg-TA062-Ag-2; GM-Tg-equg-TA062-Ag-1/ GM-Tg-equg-TA062-Ag-2
Products Name Alpha Tubulin/TUBA1A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Alpha Tubulin/TUBA1A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Alpha Tubulin/TUBA1A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.