Recombinant multi-species PYGL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PYGL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
The Alternative Names of target: PYGL,Glycogen phosphorylase, liver form,GSD6

Target products collectionGo to PYGL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-TA018-Ab-1/ GM-Tg-hg-TA018-Ab-2 Human PYGL protein Human
GM-Tg-rg-TA018-Ab-1/ GM-Tg-rg-TA018-Ab-2 Rat PYGL protein Rat
GM-Tg-mg-TA018-Ab-1/ GM-Tg-mg-TA018-Ab-2 Mouse PYGL protein Mouse
GM-Tg-cynog-TA018-Ab-1/ GM-Tg-cynog-TA018-Ab-2 Cynomolgus/Rhesus macaque PYGL monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-TA018-Ab-1/ GM-Tg-felg-TA018-Ab-2 Feline PYGL protein Feline
GM-Tg-cang-TA018-Ab-1/ GM-Tg-cang-TA018-Ab-2 Canine PYGL protein Canine
GM-Tg-bovg-TA018-Ab-1/ GM-Tg-bovg-TA018-Ab-2 Bovine PYGL protein Bovine
GM-Tg-equg-TA018-Ab-1/ GM-Tg-equg-TA018-Ab-2 Equine PYGL protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-TA018-Ab-1/ GM-Tg-hg-TA018-Ab-2; GM-Tg-rg-TA018-Ab-1/ GM-Tg-rg-TA018-Ab-2;
GM-Tg-mg-TA018-Ab-1/ GM-Tg-mg-TA018-Ab-2; GM-Tg-cynog-TA018-Ab-1/ GM-Tg-cynog-TA018-Ab-2;
GM-Tg-felg-TA018-Ab-1/ GM-Tg-felg-TA018-Ab-2; GM-Tg-cang-TA018-Ab-1/ GM-Tg-cang-TA018-Ab-2;
GM-Tg-bovg-TA018-Ab-1/ GM-Tg-bovg-TA018-Ab-2; GM-Tg-equg-TA018-Ab-1/ GM-Tg-equg-TA018-Ab-2
Products Name PYGL protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PYGL
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PYGL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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